 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 4 | 1/1 | 返回列表 |
| 查看: 638 | 回復(fù): 3 | ||
| 【懸賞金幣】回答本帖問題，作者乞丐一樣將贈(zèng)送您 5 個(gè)金幣 | ||
[求助]
求助各位大佬一篇付費(fèi)文獻(xiàn)
|
||
|
Exenatide-loaded microsphere/ thermosensitive hydrogel long-acting delivery system with high drug bioactivity 作者:Wang, PX (Wang, Puxiu) [1] ; Zhuo, XZ (Zhuo, Xuezhi) [1] ; Chu, W (Chu, Wei) [1] ; Tang, X (Tang, Xing) [1] 卷528 期1-2 頁(yè)62-75 DOI10.1016/j.ijpharm.2017.05.069 出版時(shí)間AUG 7 2017 已索引2017-08-07 文獻(xiàn)類型Article 摘要 A series of mixed hydrogels of PLGA-PEG-PLGA and PCLA-PEG-PCLA were synthesized, and investigated in terms of their critical micelle concentration, stability and thermosensitive properties. Also, some mixed hydrogel was selected to prepare Depot-gel-in-Ms-in-Matrix-gel system for the treatment of type 2 diabetes mellitus. Briefly, Exenatide (EXT) loaded hydrogels was encapsulated in PLGA microspheres (Ms) and further encapsulated into blank hydrogel. The mechanism of Exenatide release involved drug diffusion, hydrogel diffusion, PLGA erosion and mixed hydrogel erosion. The results showed that EXT release in vitro was at a sustained rate for 46 days, because it is controlled by the inner-deport-gel, the Ms matrix and the outer-Matrix-gel successively. No burst release or platform was observed due to the interception function and control function of the outer-Matrix-gel. The biological activity of EXT was protected, because the hydrophilic EXT molecules tend to distribute in the hydrophilic domain of the mixed hydrogel. In vivo, a single injection of Depot-gel-in-Ms-in-Matrix-gel allowed mice to maintain a stable blood glucose concentration and well-controlled body weight for 20 days. In addition, results of oral glucose tolerance test and Hematoxylin-Eosin staining demonstrated that triple-barrier Depot-gelin-Ms-in-Matrix-gel was a promising hydrophilic protein/polypeptide-loaded long-acting system with high drug bioactivity. (C) 2017 Elsevier B.V. All rights reserved. 關(guān)鍵詞 作者關(guān)鍵詞ExenatidePeptideHydrogelPLGA microspheresPolymeric micelles Keywords PlusPCLA-PEG-PCLABIODEGRADABLE TRIBLOCK COPOLYMERTYPE-2 DIABETES-MELLITUSCONTROLLED-RELEASEPLGA MICROSPHERESMOLECULAR-WEIGHTPOLYMERIC NANOPARTICLESBIOMEDICAL APPLICATIONSDEGRADATION PROPERTIESINTRAVITREAL DELIVERY 作者信息 通訊作者地址 Tang, Xing (通訊作者) Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 地址 1 Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 電子郵件地址tanglab@126.com 類別/分類 研究方向Pharmacology & Pharmacy 引文主題 2 Chemistry 2.53 Polymers & Macromolecules 2.53.371 Hydrogels |
回復(fù)此樓» 猜你喜歡
281求調(diào)劑（0805）
已經(jīng)有15人回復(fù)
-
085600材料與化工調(diào)劑 324分
已經(jīng)有8人回復(fù)
-
能源材料化學(xué)課題組招收碩士研究生8-10名
已經(jīng)有10人回復(fù)
-
267一志愿南京工業(yè)大學(xué)0817化工求調(diào)劑
已經(jīng)有8人回復(fù)
-
274求調(diào)劑
已經(jīng)有4人回復(fù)
-
328求調(diào)劑，英語(yǔ)六級(jí)551，有科研經(jīng)歷
已經(jīng)有10人回復(fù)
-
328求調(diào)劑，英語(yǔ)六級(jí)551，有科研經(jīng)歷
已經(jīng)有7人回復(fù)
-
材料專業(yè)求調(diào)劑
已經(jīng)有5人回復(fù)
-
一志愿天津大學(xué)化學(xué)工藝專業(yè)（081702）315分求調(diào)劑
已經(jīng)有10人回復(fù)
-
344求調(diào)劑
已經(jīng)有7人回復(fù)
zyqchem
木蟲之王 (文學(xué)泰斗)
- PhEPI: 1
- 應(yīng)助: 158 (高中生)
- 金幣: 283798
- 紅花: 552
- 沙發(fā): 1960
- 帖子: 54935
- 在線: 11795.2小時(shí)
- 蟲號(hào): 3786654
- 注冊(cè): 2015-04-04
- 專業(yè): 合成藥物化學(xué)
2樓2023-02-24 21:16:50
3樓2023-02-25 15:29:07
zyqchem
木蟲之王 (文學(xué)泰斗)
- PhEPI: 1
- 應(yīng)助: 158 (高中生)
- 金幣: 283798
- 紅花: 552
- 沙發(fā): 1960
- 帖子: 54935
- 在線: 11795.2小時(shí)
- 蟲號(hào): 3786654
- 注冊(cè): 2015-04-04
- 專業(yè): 合成藥物化學(xué)
4樓2023-02-25 15:57:46
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 乞丐一樣 的主題更新
| 4 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 070303一志愿西北大學(xué)學(xué)碩310找調(diào)劑 +6 | d如愿上岸 2026-03-12 | 9/450 |
|
|---|---|---|---|---|
|
[考研] 311求調(diào)劑 +3 | 冬十三 2026-03-18 | 3/150 |
|
|
|
[考研] 26調(diào)劑/材料/英一數(shù)二/總分289/已過A區(qū)線 +7 | 步川酷紫123 2026-03-13 | 7/350 |
|
|
|
[考研] 化學(xué)工程321分求調(diào)劑 +15 | 大米飯！ 2026-03-15 | 18/900 |
|
|
|
[考研] 085601材料工程專碩求調(diào)劑 +6 | 慕寒mio 2026-03-16 | 6/300 |
|
|
|
[考研] 材料專碩306英一數(shù)二 +10 | z1z2z3879 2026-03-16 | 13/650 |
|
|
|
[考研] 0703化學(xué)調(diào)劑 +4 | pupcoco 2026-03-17 | 7/350 |
|
|
|
[考博] 環(huán)境領(lǐng)域全國(guó)重點(diǎn)實(shí)驗(yàn)室招收博士1-2名 +3 | QGZDSYS 2026-03-13 | 5/250 |
|
|
|
[考研] 290求調(diào)劑 +3 | p asserby. 2026-03-15 | 4/200 |
|
|
|
[考研] 26考研求調(diào)劑 +6 | 丶宏Sir 2026-03-13 | 6/300 |
|
|
|
[考研] 有沒有道鐵/土木的想調(diào)劑南林，給自己招師弟中～ +3 | TqlXswl 2026-03-16 | 7/350 |
|
|
|
[考研]
 11408 一志愿西電，277分求調(diào)劑
+3
|
zhouzhen654 2026-03-16 | 3/150 |
|
|
|
[考研] 0703一志愿211 285分求調(diào)劑 +5 | ly3471z 2026-03-13 | 5/250 |
|
|
|
[考研] 0703 物理化學(xué)調(diào)劑 +3 | 我可以上岸的對(duì)?/a> 2026-03-13 | 5/250 |
|
|
|
[考研] 本科南京大學(xué)一志愿川大藥學(xué)327 +3 | 麥田耕者 2026-03-14 | 3/150 |
|
|
|
[考研] 復(fù)試調(diào)劑 +3 | 呼呼？~+123456 2026-03-14 | 3/150 |
|
|
|
[考研] 26調(diào)劑/材料科學(xué)與工程/總分295/求收留 +9 | 2026調(diào)劑俠 2026-03-12 | 9/450 |
|
|
|
[考研] 290求調(diào)劑 +3 | ADT 2026-03-13 | 3/150 |
|
|
|
[考博] 福州大學(xué)楊黃浩課題組招收2026年專業(yè)學(xué)位博士研究生，2026.03.20截止 +3 | Xiangyu_ou 2026-03-12 | 3/150 |
|
|
|
[考博] 26讀博 +4 | Rui135246 2026-03-12 | 10/500 |
|