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| The initial speculation of DLL4 signaling involvement in tumor angiogenesis came from expression analyses of DLL4. Results from a flurry of recent studies confirmed that targeting DLL4/NOTCH1 signaling has a profound impact on tumor angiogenesis and growth.Pathway blockade was achieved using either a DLL4-selective neutralizing antibody , a NOTCH1-selective antagonistic antibody, a soluble DLL4 fusion protein, or a soluble NOTCH fusion protein. These reagents demonstrated broad and robust anti-tumor activity in a wide variety of tumor models. |
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| DLL4(Delta like ligand 4,德爾塔樣配體4)信號參與腫瘤血管生成的最初推測來自DLL4的表達分析。最近的研究證實,靶向DLL4/NOTCH1信號對腫瘤血管生成和增長產(chǎn)生深遠的影響。通路阻滯可使用DLL4選擇性中和抗體,NOTCH1選擇性拮抗(競爭)性抗體,可溶性DLL4融合蛋白或可溶性NOTCH融合蛋白實現(xiàn)。這些試劑經(jīng)證實在多種腫瘤模型具有廣泛和強大的抗腫瘤活性。 |

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