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Intriguingly, the innovation of a fragment-based drug design (FBDD) approach has enabled rapid and efficient progress in drug discovery. In this critical review, we focus on the construction of fragment libraries and the advantages and disadvantages of various fragment-based screening (FBS) for constructing such libraries. We also highlight the deconstruction–reconstruction strategy by utilizing privileged fragments of reported ligands. 發(fā)自小木蟲Android客戶端 |
銅蟲 (著名寫手)
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Intriguingly, the innovation of a fragment-based drug design (FBDD) approach has enabled rapid and efficient progress in drug discovery. In this critical review, we focus on the construction of fragment libraries and the advantages and disadvantages of various fragment-based screening (FBS) for constructing such libraries. We also highlight the–reconstruction strategy by utilizing privileged fragments of reported ligands. 有趣的是,新發(fā)明的一種基于片斷的藥物設(shè)計(jì)方法使藥物的發(fā)現(xiàn)過程變得快速和有效。在本評(píng)論性綜述中,我們專注于片斷文庫的建構(gòu)以及各種用于建造這些文庫的基于片斷的篩選方法的利弊。我們也強(qiáng)調(diào)通過利用已見報(bào)的(配位體的)有授權(quán)的片斷來解構(gòu)和重建文庫的策略方法。 |
金蟲 (小有名氣)
新蟲 (初入文壇)
金蟲 (小有名氣)
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