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summer2771木蟲 (正式寫手)
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| 如題，煩請在WOS內(nèi)檢索一篇論文Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice是否被SCI收錄，我沒有權(quán)限。謝謝！ |
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小凡下山
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summer2771: 金幣+20, ★★★★★最佳答案, 非常感謝兄弟的幫助！ 2016-10-01 18:53:29
summer2771: 金幣+20, ★★★★★最佳答案, 非常感謝兄弟的幫助！ 2016-10-01 18:53:29
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paperhunter: 金幣+10, 鼓勵交流 2016-10-01 15:29:22
感謝參與，應(yīng)助指數(shù) +1
paperhunter: 金幣+10, 鼓勵交流 2016-10-01 15:29:22
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Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice 作者:Xia, Z (Xia, Zhi)[ 1,2 ] ; Cholewa, J (Cholewa, Jason)[ 3 ] ; Zhao, Y (Zhao, Yan)[ 1 ] ; Yang, YQ (Yang, Yue-Qin)[ 2 ] ; Shang, HY (Shang, Hua-Yu)[ 4 ] ; Guimaraes-Ferreira, L (Guimaraes-Ferreira, Lucas)[ 5 ] ; Naimo, MA (Naimo, Marshall Alan)[ 6 ] ; Su, QS (Su, Quan-Sheng)[ 7 ] ; Zanchi, NE (Zanchi, Nelo Eidy)[ 8,9 ] 查看 ResearcherID 和 ORCID NUTRIENTS 卷: 8 期: 5 文獻號: 246 DOI: 10.3390/nu8050246 出版年: MAY 2016 查看期刊信息 摘要 Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1 (R) mice were subjected to moderate aerobic exercise (45 min swimming per day with 3% body weight workload) and fed a chow diet with 5% leucine or 3.4% alanine for 8 weeks. Serum and plasma were prepared for glucose, urea nitrogen, insulin and amino acid profile analysis. The white gastrocnemius muscles were used for determination of muscle size and signaling proteins involved in protein synthesis and degradation. The results show that both 8 weeks of leucine supplementation and aerobic training elevated the activity of mTOR (mammalian target of rapamycin) and its downstream target p70S6K and 4E-BP1, inhibited the ubiquitin-proteasome system, and increased fiber cross-sectional area (CSA) in white gastrocnemius muscle. Moreover, leucine supplementation in combination with exercise demonstrated more significant effects, such as greater CSA, protein content and altered phosphorylation (suggestive of increased activity) of protein synthesis signaling proteins, in addition to lower expression of proteins involved in protein degradation compared to leucine or exercise alone. The current study shows moderate aerobic training combined with 5% leucine supplementation has the potential to increase muscle size in fast-twitch skeletal muscle during aging, potentially through increased protein synthesis and decreased protein breakdown. 關(guān)鍵詞 作者關(guān)鍵詞:leucine-rich diet; aerobic exercise; aging; protein metabolism KeyWords Plus:MUSCLE PROTEIN-SYNTHESIS; HUMAN SKELETAL-MUSCLE; CHAIN AMINO-ACIDS; RESISTANCE EXERCISE; ENDURANCE EXERCISE; DIABETES-MELLITUS; OLDER-PEOPLE; EXPRESSION; RATS; SARCOPENIA 作者信息 通訊作者地址: Zanchi, NE (通訊作者) 顯示增強組織信息的名稱 Fed Univ Maranhao UFMA, Dept Phys Educ, BR-65020070 Sao Luis, MA, Brazil. 通訊作者地址: Zanchi, NE (通訊作者) Lab Cellular & Mol Biol Skeletal Muscle LABCEMME, BR-65020070 Sao Luis, MA, Brazil. 地址: 顯示增強組織信息的名稱 [ 1 ] Jinggangshan Univ, Coll Phys Educ, Exercise Physiol & Biochem Lab, Jian 343009, Jiangxi, Peoples R China [ 2 ] Wuhan Sports Univ, Exercise Intervent & Hlth Promot Hubei Prov Syner, Wuhan 430079, Peoples R China 顯示增強組織信息的名稱 [ 3 ] Coastal Carolina Univ, Dept Kinesiol, Conway, SC 29528 USA 顯示增強組織信息的名稱 [ 4 ] Beijing Sport Univ, Dept Exercise Physiol, Exercise Physiol Lab, Beijing 100084, Peoples R China 顯示增強組織信息的名稱 [ 5 ] Univ Fed Espirito Santo, Ctr Phys Educ & Sports, Muscle Physiol & Human Performance Res Grp, BR-29075810 Vitoria, ES, Brazil 顯示增強組織信息的名稱 [ 6 ] W Virginia Univ, Div Exercise Physiol, Sch Med, Morgantown, WV 26506 USA [ 7 ] Chengdu Sport Univ, Dept Sports Med, Chengdu 610041, Peoples R China 顯示增強組織信息的名稱 [ 8 ] Fed Univ Maranhao UFMA, Dept Phys Educ, BR-65020070 Sao Luis, MA, Brazil [ 9 ] Lab Cellular & Mol Biol Skeletal Muscle LABCEMME, BR-65020070 Sao Luis, MA, Brazil 電子郵件地址:zhixia.ep@hotmail.com; jcholewa@coastal.edu; baihu0098@163.com; yangyueqin226@163.com; santanasan@163.com; lgtrainer@yahoo.com.br; man03e@my.fsu.edu; sqs111@126.com; neloz@ig.com.br 基金資助致謝 基金資助機構(gòu) 授權(quán)號 Jiangxi Province Science Foundation for Youths 20142BAB215048 Scientific Research Foundation for PhD in Jinggangshan University JZB15014 查看基金資助信息 出版商 MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND 類別 / 分類 研究方向:Nutrition & Dietetics Web of Science 類別:Nutrition & Dietetics 文獻信息 文獻類型:Article 語種:English 入藏號: WOS:000378780900007 ISSN: 2072-6643 期刊信息 Impact Factor (影響因子): Journal Citation Reports® 其他信息 IDS 號: DP8XI Web of Science 核心合集中的 "引用的參考文獻": 57 Web of Science 核心合集中的 "被引頻次": 0 |
2樓2016-10-01 15:15:53
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