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小云云。新蟲 (小有名氣)
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[求助]
求大神幫忙把下面兩段的文獻(xiàn)摘要翻譯成中文。。。
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1 A single mutation within a flavoprotein is capable of switching the catalytic activity of a dehalogenase into a nitroreductase. This change in function correlates with a destabilization of the one-electron-reduced flavin semiquinone that is differentially expressed in the nitro-FMN reductase superfamily during redox cycling. The diversity of function within such a superfamily therefore has the potential to arise from rapid evolution, and its members should provide a convenient basis for developing new catalysts with an altered specificity of choice. 2 The coordination bond between gold and sulfur (Au–S) has been widely studied and utilized in many fields. However, detailed investigations on the basic nature of this bond are still lacking. A gold-specific binding protein, GolB, was recently identified, providing a unique opportunity for the study of the Au–S bond at the molecular level. We probed the mechanical strength of the gold–sulfur bond in GolB using single-molecule force spectroscopy. We measured the rupture force of the Au–S bond to be 165 pN, much lower than Au–S bonds measured on different gold surfaces (∼1000 pN). We further solved the structures of apo-GolB and Au(I)–GolB complex using X-ray crystallography. These structures showed that the average Au–S bond length in GolB is much longer than the reported average value of Au–S bonds. Our results highlight the dramatic influence of the unique biological environment on the stability and strength of metal coordination bonds in proteins. |
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disjustar
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jnxybsf
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【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★
小云云。: 金幣+6, ★★★很有幫助 2015-12-08 12:09:23
愛與雨下: 金幣+1 2015-12-08 21:31:35
小云云。: 金幣+6, ★★★很有幫助 2015-12-08 12:09:23
愛與雨下: 金幣+1 2015-12-08 21:31:35
| 金硫配位鍵已在眾多領(lǐng)域得到了廣泛研究及應(yīng)用，但對于該鍵的基礎(chǔ)性質(zhì)還有待研究。近來，一種含有特定金建的蛋白質(zhì)GolB已被確定，這為在分子水平上研究金-硫鍵提供了獨(dú)特的條件。我們用單分子力光譜檢測了GOlB中金-硫鍵的機(jī)械強(qiáng)度。該金-硫鍵的斷裂力為165pN,遠(yuǎn)小于不同金原子表面的金-硫鍵(約1000pN).我們進(jìn)一步用x射線結(jié)晶法確定了apo-GolB and Au(I)–GolB復(fù)合物的結(jié)構(gòu)，結(jié)果表明GolB中金-硫鍵的平均鍵長遠(yuǎn)大于所報道的值。研究結(jié)果強(qiáng)調(diào)了獨(dú)特的生物環(huán)境對蛋白質(zhì)中金屬配位鍵的穩(wěn)定性和強(qiáng)度的顯著影響 我是外行，僅供參考 |
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