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Strawberrix新蟲 (小有名氣)
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[交流]
metabolic modelling （荷蘭馬斯特里赫特大學），無需語言成績，截止日期4/15
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荷蘭maastricht university與csc的項目，荷蘭方面maastricht university免學費，csc方面提供生活費，截止日期是4/15日。項目開始日期可商議，可能在10-12月，也可在線上擇時開始展開。 dr. marian breuer學識淵博，擁有在美國illinois urbana-champaign, 英國university college london等名校學習和科研經驗，為人非常有耐心，相信他會手把手帶學生。荷蘭的教學質量很高，生活宜居。荷蘭人的英文水平普遍較好，可用英語直接交流。 馬斯特里赫特大學（英文：maastricht university），是一所年輕但是享譽世界的名校。大學組建于1974年9月16日，前身為國立林堡大學，也是荷蘭13所國立研究型大學之一，為世界大學聯盟成員。 中心網站 www.maastrichtuniversity.nl/rese ... tre-systems-biology 對生源的要求：需要有較好的英語溝通能力（硬性的語言成績不一定要有）。具有生化/計算機兩者至少其一的相關背景。 感興趣者請將英文版cv和transcript發(fā)送至 dr. marian breuer, marian.breuer@maastrichtuniversity.nl， 并咨詢其他信息。 project title: targeting cellular ageing and senescence through metabolic modelling project leader: dr. marian breuer function: assistant professor collaborators: dr. michiel adriaens, prof. dr. ilja arts introduction: the ageing of populations creates a major public health burden around the world. ageing involves intertwined processes on cellular and tissue levels. in particular, cellular senescence, a heterogeneous phenotype of permanent growth arrest, is an important driver of ageing in tissues. interventions against ageing, e.g. by targeting this senescent state, could extend the healthy lifespan and contribute to regenerative medicine. cellular senescence has significant ties to metabolism, suggesting potential intervention strategies; however, these ties are insufficiently characterized. hypothesis and objectives: this project will study the metabolic changes accompanying cellular ageing and in particular senescence with the goal of identifying possible new signatures and biomarkers, as well as possible metabolic targets for more selective and specific drugs against senescent cells. setting and methods: metabolic networks of young, aged and senescent human cells will be reconstructed using omics data like transcriptomics and epigenomics. in silico metabolic modeling will be used to analyze and compare metabolic features between conditions. this comparison will not only shed light on the metabolic signatures of cellular ageing and senescence, but also identify intervention targets that could revert the ageing process at cellular level. impact: the discovery of specific metabolic intervention targets will aid the development of more specific anti-senescence drugs. the development of metabolic signatures and biomarkers could aid in the identification and monitoring of senescent cells, which would be necessary to study the efficacy of anti-senescence drugs. overall, this project will aid the development of anti-ageing precision medicine ╟ ultimately promoting healthy ageing in the population. requirements candidate: highly motivated student with good english communication skills and proactive and resolute attitude. the ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in matlab. applications with background in only the biochemical or computational side are still possible, but the applicant would need to make a convincing impression of being able to catch up in the other aspect. keywords: biological foundations of human health and diseases, major new drugs discovery, systems biology, metabolic modelling, ageing top 5 selected publications: 1. m. breuer, t. m. earnest, c. merryman, k. s. wise, l. sun, m. r. lynott, c. a. hutchison iii, h. o. smith, j. d. lapek jr., d. j. gonzalez, v. de crécy-lagard, d. haas, a. d. hanson, p. labhsetwar, j. i. glass, z. luthey-schulten “essential metabolism for a minimal cell” elife (2019), 8:e36842. citations (web of science): 9 2. prickaerts, p.*, adriaens, m.e.*, beucken, t.. et al. “hypoxia increases genome-wide bivalent epigenetic marking by specific gain of h3k27me3”, epigenetics & chromatin (2016), 9: 46. citations (web of science): 21 3. m. breuer, k. m. rosso, j. blumberger “electron flow in multi-heme bacterial cytochromes is a balancing act between heme electronic interaction and redox potentials”, proc. natl. acad. sci. usa (2014), 111: 611. citations (web of science): 96 4. x. jiang, b. burger, f. gajdos, c. bortolotti, z. futera, m. breuer, j. blumberger “kinetics of trifurcated electron flow in the decaheme bacterial proteins mtrc and mtrf“ proc. natl. acad. sci. usa (2019) 116: 3425. citations (web of science): 5 5. m. breuer, k. m. rosso, j. blumberger, j. n. butt “multi-haem cytochromes in shewanella oneidensis mr-1: structures, functions and opportunities”, j. r. soc. interface (2015) 12: 20141117. citations (web of science): 86 [ last edited by strawberrix on 2020-4-10 at 09:23 ] p.s. applicants should ideally receive master's degree this year, and at most should have received their master's degree last year. [ last edited by strawberrix on 2020-4-12 at 21:48 ] Deadline extended to 24th April, but the opening will be closed once a suitable candidate is found. [ Last edited by Strawberrix on 2020-4-20 at 20:15 ] |
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Strawberrix
新蟲 (小有名氣)
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- 注冊: 2014-06-07
- 專業(yè): 細胞生物學研究中的新方法
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jzyhh12345
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dongdong8881
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