It is an monocarboxylate transporter 1 (MCT1) inhibitors,MCT1 mediates lactate uptake. AZD-3965 is currently being evaluated in phase I/II clinical trials.
參考文獻如下：
1. Bueno V, Binet I, Steger U, Bundick R, Ferguson D, Murray C, et al. The specific monocarboxylate
transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival
in the mouse. Transplantation 2007; 84:1204-7; PMID:17998878; https://dx.doi.org/10.1097/01.
tp.0000287543.91765.41.
2. Ovens MJ, Davies AJ, Wilson MC, Murray CM,Halestrap AP. AR-C155858 is a potent inhibitor
of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane
helices 7–10. Biochem J 2010; 425:523-30; PMID:19929853; https://dx.doi.org/10.1042/BJ20091515，
返回小木蟲查看更多
京公網(wǎng)安備 11010802022153號
實驗性抗癌藥物吧？這個難度有點大，屬于商業(yè)機密吧
很明顯，這個是商業(yè)機密，有可能涉及到10億美刀研發(fā)經(jīng)費的問題，如果有人告訴你這個結構式，就涉及違法，要坐牢的
It is an monocarboxylate transporter 1 (MCT1) inhibitors,MCT1 mediates lactate uptake. AZD-3965 is currently being evaluated in phase I/II clinical trials.
AZD-3965 是一個最近被阿斯利康有限公司(世界第四大制藥公司)研制開發(fā)的一個抗腫瘤新藥，靶點是MCT1。目前在臨床II期試驗階段。
參考文獻如下：
1. Bueno V, Binet I, Steger U, Bundick R, Ferguson D, Murray C, et al. The specific monocarboxylate
transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival
in the mouse. Transplantation 2007; 84:1204-7; PMID:17998878; https://dx.doi.org/10.1097/01.
tp.0000287543.91765.41.
2. Ovens MJ, Davies AJ, Wilson MC, Murray CM,Halestrap AP. AR-C155858 is a potent inhibitor
of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane
helices 7–10. Biochem J 2010; 425:523-30; PMID:19929853; https://dx.doi.org/10.1042/BJ20091515，