Project Title: Green synthesis of novel nanocomposites for biomedical applications

Project Description:

In recent years, there has been increasing application of hydrogel based polymer nanocomposites in biomedical field, such as wound dressings, bone cements, tissue scaffolds, as well as cancer treatment. Nanocomposites combining hydrogel and multi-functional nanoparticles (NPs) have received particular attention, e.g. hydrogel incorporating gold or magnetic iron oxide NPs have been proposed for multi-modality cancer therapies (trauma sensing, pulsed drug delivery, bio-imaging, and hyperthermia).

In previous approaches the hydrogel based nanocomposites have been obtained by sequential mixing of pre-synthesized NPs with hydrogels. These conventional synthesis approaches of NPs are predominantly by chemical reduction (e.g. AuNPs), alkaline precipitation in water, water-in-oil microemulsion, and thermal decomposition (e.g. iron oxide NPs). These methods mostly require harsh chemicals and elevated temperature, and suffer from large NP size distribution, surface contamination by surfactants and toxicity of the organic residues, which present major challenges (limited functionality and potential safety issue) towards clinical applications. In addition, the critical element of a successful nanocomposite - controlled microstructure (NP and matrix) and long term stability (dispersion) is yet to be achieved.

The aim of the proposed project is to develop new knowledge and expertise on a chemical-free in situ green-synthesis composite technology. The project is in collaboration with School of Pharmacy and is supported by a UK leading biomedical company for the development of the novel techniques and materials. The student will have the opportunities to be trained on a wide range of state of the art material synthesis and characterization facilities and the outcome of the proposed project will be NP/hydrogel bio-nanocomposites with low toxicity, high stability and multi-functionality and these materials may demonstrate their potential capability particularly in anti-microbial applications well as other areas such as tissue engineering and drug delivery. Other planned output include conferences presentations and journal publications.


First/Lead Supervisor and their contact details:         Dr Dan Sun, d.sun@qub.ac.uk

Second Supervisor and their contact details:                 Prof Fraser Buchanan, f.buchanan@qub.ac.uk     
                                                                               Prof Brendan Gilmore, b.gilmore@qub.ac.uk

貝爾法斯特女王大學(xué)（Queen's University Belfast）于1845年由維多利亞女王建校，因此為女王大學(xué)。為英國(guó)頂尖名校，全球百?gòu)?qiáng)名校。是一所享譽(yù)歐洲的公立頂級(jí)研究型大學(xué)，該校擁有全英國(guó)和愛(ài)爾蘭頂級(jí)醫(yī)學(xué)院和工程學(xué)院，該校的醫(yī)學(xué)院，商學(xué)院，工學(xué)院以及管理學(xué)院也都在全愛(ài)爾蘭名列前茅。該大學(xué)位于英國(guó)的北愛(ài)爾蘭首府貝爾法斯特，其教研歷史悠久，學(xué)術(shù)成就昭著，是英國(guó)和愛(ài)爾蘭歷史最悠久的大學(xué)之一，并且也是英國(guó)著名的常青藤名校羅素集團(tuán)大學(xué)成員之一。
（https://baike.baidu.com/link?url ... ffxyY6DZ_qrSWrVS8hj）

貝爾法斯特女王大學(xué)機(jī)械與航空航天學(xué)院官網(wǎng)，相關(guān)招聘信息詳見(jiàn)網(wǎng)站。
https://www.qub.ac.uk/schools/Sc ... rospaceEngineering/
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導(dǎo)師簡(jiǎn)介
Dr Dan Sun, d.sun@qub.ac.uk
https://www.qub.ac.uk/schools/Sc ... emicStaff/DrDanSun/

Prof Fraser Buchanan, f.buchanan@qub.ac.uk   
https://www.qub.ac.uk/schools/Sc ... ProfFraserBuchanan/

Prof Brendan Gilmore, b.gilmore@qub.ac.uk 返回小木蟲(chóng)查看更多