大連醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院
秘曉林課題組招聘科研助理、博士后

一、課題組介紹
秘曉林，博士，教授，博士生導(dǎo)師。
現(xiàn)任大連醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院副院長(zhǎng)，生物科學(xué)系主任。中國(guó)科學(xué)院引進(jìn)國(guó)外杰出人才“百人計(jì)劃”研究員，遼寧省“攀登學(xué)者”，入選遼寧省“十百千人才工程”。國(guó)家科技獎(jiǎng)、香山會(huì)議、國(guó)家重大科學(xué)研究計(jì)劃項(xiàng)目、自然科學(xué)基金、博士后基金、美國(guó)自然科學(xué)基金研究生項(xiàng)目等評(píng)議人，多個(gè)SCI雜志編委，及Biomaterials, Genetics, Environmental Toxicology and Pharmacology, Food and Chemical Toxicology，International Journal of Nanomedicine，PLoS One等雜志審稿人。承擔(dān)國(guó)家重點(diǎn)基礎(chǔ)研究計(jì)劃“973”項(xiàng)目、自然科學(xué)基金面上項(xiàng)目、中國(guó)科學(xué)院創(chuàng)新項(xiàng)目等。作為通訊作者或第一作者，在Proceedings of National Academy of Science USA(PNAS), Current Biology, Oncogene, Human Molecular Genetics, Molecular and Cellular Biology, Biomaterials, Journal of Cell Science, Genetics，Nanotoxicology等國(guó)際一流學(xué)術(shù)期刊發(fā)表高水平學(xué)術(shù)論文多篇。
研究方向
主要致力于基因組穩(wěn)定性的保護(hù)和干細(xì)胞再生與分化的調(diào)控機(jī)制及其與疾病的關(guān)系等。研究方向包括：DNA損傷導(dǎo)致的細(xì)胞周期調(diào)節(jié)、凋亡、轉(zhuǎn)錄調(diào)控的機(jī)制；腸道干細(xì)胞再生與分化的調(diào)節(jié)；非編碼RNA在DNA損傷應(yīng)答的功能和調(diào)控及對(duì)腸道干細(xì)胞再生與分化的調(diào)控；腫瘤抑制因子對(duì)DNA損傷導(dǎo)致的細(xì)胞周期檢驗(yàn)點(diǎn)、凋亡的調(diào)控，在抑制腫瘤發(fā)生和發(fā)展中的作用和機(jī)制。
代表性文章（*通訊作者）
1. Cong, W., Wang, P., Qu, Y., Tang, J., Bai, R., Zhao, Y., Chen, C. , Bi, X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86.  IF 8.6
2. Chen, H., Wang, B., Feng, W., Du, W., Ouyang, H., Chai, Z., Bi, X.*  Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312.  IF 6.4
3. Yuan, Q., Han, J., Cong, W., Ge, Y., Ma, D., Dai, Z., Li, Y. *, Bi, X. * Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity. International Journal of Nanomedicine. 2014.  9(1): 4829-4846.  IF 4.4
4. Fang, G., Zhang, D., Yin, H., Zheng, L., Bi, X.*, Yuan, L.*  Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of  Cell Science. 2014.  127 :1631-1639.  IF 5.9
5. Wang, Y., Wang, Z., Joshi, BH., Puri, R., Stultz, B., Yuan, Q., Bai, Y., Zhou, P., Yuan, Z., Hursh, DA., Bi, X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-66.  IF 8.6
6. Liu, W., Jiang, F., Bi, X.*, Zhang, Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-68.  IF 7.7
7. Kong, L., Yuan Y., Zhu, H., Li, Y., Guo, Q., Zhao, Y., Wang, Q., Bi, X.*, Gao,X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522.  IF 7.6
8. Wang, P., Bai, Y., Song, B., Wang, Y., Liu, D., Lai, Y., Bi, X.*, Yuan, Z*. PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE. 2011.6(9):e24288.  IF 4.3
9. Gao, G., Bi, X., Chen, J., Srikanta, D., Rong, YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proc. Nat. Acad. Sci. USA. 2009. 106(26): 10728–10733.(Equal contribution).  IF 9.8
10. Bi, X., Jones, T., Abbasi, F., Lee, H., Stultz, B., Hursh, D., Mortin, M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239.  IF 6.8
11. Bi, X., Srikanta, D., Fanti,L., Pimpinelli,S., Badugu,R., Kellum,R., Rong, Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc. Nat. Acad. Sci. USA. 2005. 102(42):15167-15172.  IF 9.8
12. Bi, X., Gong, M., Srikanta, D., Rong, Y.S. Drophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005. 171:845-847.  IF 4.4
13. Bi, X., Wei, S.D., Rong, Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Curr. Biol. 2004. 14:1348-1353.  IF 11.9
14. Bi, X., Kajava, A., Demidenko, Z., Jones, T., Mortin, M. The carboxyl terminus of Prospero regulates its subcellular localization.  Mol. Cell. Biol.  2003.23 (3): 1014-1024.   IF 8.9

二、職位描述
崗位屬性：副教授或講師1人，開展科研工作，協(xié)助指導(dǎo)研究生，管理實(shí)驗(yàn)室。
崗位要求：生命科學(xué)或醫(yī)學(xué)相關(guān)專業(yè)博士畢業(yè)，熟悉細(xì)胞生物學(xué)、遺傳學(xué)知識(shí)，掌握果蠅遺傳操作；或熟悉蛋白質(zhì)表達(dá)、純化、定位、修飾、相互作用，以及蛋白質(zhì)與RNA相互作用等生物化學(xué)知識(shí)。
待遇：
1. 大連醫(yī)科大學(xué)正式編制，根據(jù)所發(fā)文章情況評(píng)定副教授或講師；
2. 工資待遇依據(jù)學(xué)校文件與職稱對(duì)應(yīng)。

崗位屬性：博士后1人，開展科研工作；
崗位要求：同前。

三、應(yīng)聘者請(qǐng)?zhí)峁┮韵虏牧?br /> 1. 個(gè)人簡(jiǎn)歷（包括教育學(xué)習(xí)經(jīng)歷及工作經(jīng)歷、發(fā)表論文清單和首頁(yè)，含一寸免冠照片）；
2. 推薦信2封；
3. 其它能證明本人能力的材料。
有意者請(qǐng)將申請(qǐng)材料發(fā)送至以下郵箱，郵件標(biāo)題請(qǐng)注明：科研助理+畢業(yè)院校+姓名，或博士后+畢業(yè)院校+姓名。

聯(lián)系人：秘曉林
郵箱：bixl@dmu.edu.cn 或 xl2000bi@163.com 返回小木蟲查看更多