饒燏實(shí)驗(yàn)室與魏文毅實(shí)驗(yàn)室招聘聯(lián)合博士后開(kāi)展基于蛋白質(zhì)降解技術(shù)的化學(xué)生物學(xué)研究及相關(guān)轉(zhuǎn)化醫(yī)學(xué)研究。
應(yīng)聘時(shí)間：從2019年1月起，招滿為止。 招聘人數(shù)：2人
研究方向：開(kāi)展基于蛋白質(zhì)降解技術(shù)的化學(xué)生物學(xué)及相關(guān)轉(zhuǎn)化醫(yī)學(xué)研究。
關(guān)于蛋白質(zhì)降解技術(shù)的研究背景,可參考饒燏教授課題組近期在Cell Research發(fā)表的研究論文:《利用新型蛋白質(zhì)靶向降解技術(shù)克服Ibrutinib耐藥的B細(xì)胞惡性腫瘤》PROTAC-Induced BTK Degradation as a Novel Therapy for Mutated BTK C481S Induced Ibrutinib-Resistant B-Cell Malignancies
應(yīng)聘條件：
1. 對(duì)前沿藥物發(fā)現(xiàn)，藥物化學(xué)，相關(guān)生物學(xué)機(jī)制研究，藥理學(xué)或轉(zhuǎn)化醫(yī)學(xué)工作有強(qiáng)烈的興趣。
2. 博士研究背景為生物學(xué)，藥理學(xué)，有機(jī)化學(xué)，藥物化學(xué)，醫(yī)學(xué)或相關(guān)領(lǐng)域。
3. 工作作風(fēng)積極肯干，并有志于今后在藥學(xué)及轉(zhuǎn)化醫(yī)學(xué)研究的學(xué)術(shù)科研領(lǐng)域有所發(fā)展。有良好的與人相處和溝通的能力及團(tuán)隊(duì)合作精神。
待遇：實(shí)驗(yàn)室將為博士后提供高水平的實(shí)驗(yàn)平臺(tái)及科研環(huán)境，其它待遇按照清華大學(xué)相關(guān)規(guī)定執(zhí)行（具體情況參見(jiàn)清華大學(xué)博士后申請(qǐng)相關(guān)網(wǎng)頁(yè)）。優(yōu)秀的申請(qǐng)人將推薦申請(qǐng)生命科學(xué)聯(lián)合中心博士后基金。具體參見(jiàn)：https://www.cls.edu.cn/
聯(lián)系人：饒燏 老師
申請(qǐng)材料：申請(qǐng)人的個(gè)人簡(jiǎn)歷及詳細(xì)的工作經(jīng)歷和研究成果，并提供2-3位推薦人的姓名及聯(lián)系方式。請(qǐng)將申請(qǐng)材料發(fā)至：raolabthu_1@163.com
哈佛大學(xué)醫(yī)學(xué)院魏文毅教授課題組研究簡(jiǎn)介：
The Wei lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School focuses on understanding how Ubiquitin E3 ligase APC (Wei et al., Nature 428: 194, 2004; Gao et at Nature Cell Biology 11: 397, 2009; Wan et al, Molecular Cell 44: 721, 2011, Wan et al, Developmental Cell 29:377, 2014) and SCF (Wei et al., Cancer Cell 8: 25, 2005; Inuzuka et al, Cancer Cell 18:147, 2010; Inuzuka et al, Nature 471:104, 2011; Gao et al, Molecular Cell 44: 290, 2011; Inuzuka et al, Cell 150(1): 179, 2012) activities contribute to cell cycle regulation and subsequent tumor formation, as well as how PTEN/Akt signaling pathway governs tumorigenesis (Liu et al, Nature 508: 541, 2014; Liu et al, Cancer Discovery 5:1194, 2015; Guo, et al, Science, 353:929; 2016). Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling, and close collaboration with the Yu Rao group at Tsinghua University to understand how PROTAC technology can achieve targeted degradation of endogenous proteins in both cell culture and animal models. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.
Detailed publications of the Wei lab can be seen at
Please also visit Wei lab at https://www.hms.harvard.edu/dms/bbs/fac/wei.php
Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and 2-3 references to Dr. Yu Rao at raolabthu_1@163.com 返回小木蟲(chóng)查看更多