驢脦脤芒脳茅魯隴錄貌陸茅

麓壟脕貓?zhí)斅┟婓H2012脛錨鹵戮驢脝鹵脧脪碌脫脷脰脨鹿煤驢脝脩摟錄錄脢玫麓貿(mào)脩摟祿爐脩摟脧碌攏盧2017脛錨脫脷脣鹿驢脣脌茂脝脮脣鹿脩脨戮驢脣霉祿帽碌脙祿爐脩摟虜漏脢驢脩摟脦祿隆攏虜漏脢驢脝脷錄盲脢婁麓脫脰酶脙沒脫脨祿煤祿爐脩摟錄脪Jin-Quan Yu陸脤脢脷攏盧麓脫脢脗卯脵麓脽祿爐脤錄脟芒錄眉祿卯祿爐路麓脫婁碌脛脩脨戮驢隆攏脥盧脛錨7脭脗祿帽碌脙Brown-Coxe虜漏脢驢潞貿(mào)陸鹵脩摟陸冒虜壟錄脫脠毛脪廬脗魯麓貿(mào)脩摟驢陋脢錄祿爐脩摟脡煤脦茂脩摟脩脨戮驢攏盧潞脧脳梅碌錄脢婁脦陋脙脌鹿煤鹿煤錄脪驢脝脩摟脭潞錄擄脪脮脢玫驢脝脩摟脭潞脭潞脢驢Alanna Schepartz陸脤脢脷潞脥Derek Toomre陸脤脢脷隆攏脭脷麓脣脝脷錄盲路壟脮鹿脕脣祿霉脫脷脨隆路脰脳脫脤陸脮毛碌脛露脿脡蘆隆壟魯隴脢鹵錄盲隆壟魯盧賂脽路脰鹵忙祿卯脧賂擄沒脫蘆鹿芒魯脡脧帽錄錄脢玫隆攏脣沒脫脷2019脛錨錄脫脠毛PROTAC脕矛脫貌麓麓脢錄脠脣Craig Crews陸脤脢脷驢脦脤芒脳茅麓脫脢脗祿爐脩摟脡煤脦茂脩摟錄擄脪漏脦茂祿爐脩摟脩脨戮驢隆攏脭脷麓脣脝脷錄盲脡貓錄脝虜壟潞脧魯脡脕脣脢脳賂枚脛脺鹿祿陸碌陸芒脰脗擄漏碌擄擄脳KRAS碌脛碌擄擄脳陸碌陸芒擄脨脧貌脟露潞脧脤氓 (PROTAC)隆攏脝盲脩脨戮驢魯脡鹿沒路壟鹵鉚脫脷Science, Nature Chemistry, Nature Communications碌脠脭脫脰戮攏盧脳脺脪媒脫脙脢媒魯盧脟摟麓脦隆攏麓壟脕貓?zhí)斅┟婓H脫脷2021脛錨3脭脗錄脫脠毛脟氓祿陋麓貿(mào)脩摟脪漏脩摟脭潞驢陋脮鹿露脌脕壟脩脨戮驢攏盧脩脨戮驢路陸脧貌脦陋祿爐脩摟脡煤脦茂脩摟攏盧脨脗脪漏脩脨路壟錄擄脨脗脨脥脡煤脦茂魯脡脧帽錄錄脢玫碌脛驢陋路壟隆攏

驢脦脤芒脳茅脰梅脪魯攏潞chu-lab.org
www.sps.tsinghua.edu.cn/cn/team/team/2021/0323/110.html
脕陋脧碌路陸脢陸攏潞lingchu@mail.tsinghua.edu.cn

脪貌驢脦脤芒路壟脮鹿脨貓脟貿(mào)攏盧驢脦脤芒脳茅脮脨脝賂戮脽脫脨脫脨祿煤潞脧魯脡祿貌陸冒脢么麓脽祿爐脨脗路麓脫婁驢陋路壟脧脿鹿脴戮顱脩茅碌脛虜漏脢驢潞貿(mào)2-3脙沒攏盧脰梅脪陋麓脫脢脗脨脗脨脥脡煤脦茂脮媒陸祿路麓脫婁碌脛驢陋路壟脪脭錄擄脨隆路脰脳脫脫蘆鹿芒脤陸脮毛碌脛驢陋路壟碌脠鹿隴脳梅隆攏

脮脨脝賂脪陋脟貿(mào)

1. 路沒潞脧脟氓祿陋麓貿(mào)脩摟虜漏脢驢潞貿(mào)脮脨脢脮脤玫錄鎂攏祿
2. 脪脩戮顱祿貌脮脽錄麓陸蘆脭脷SCI脝脷驢爐脪脭碌脷脪祿脳梅脮脽路壟鹵鉚脗脹脦脛攏盧脛脺鹿祿露脌脕壟驢陋脮鹿驢脝脩脨鹿隴脳梅攏祿
3. 戮脽脫脨脫脨祿煤祿爐脩摟隆壟脪漏脦茂祿爐脩摟碌脠脧脿鹿脴脩脨戮驢鹵魯戮擄攏祿
4. 脫脨鹿媒露脡陸冒脢么麓脽祿爐路麓脫婁脧脿鹿脴脩脨戮驢戮顱脩茅脮脽脫脜脧脠攏祿
5. 戮脽脫脨賂脽露脠碌脛脭冒脠脦脨脛潞脥脡脧陸酶脨脛攏盧鹿隴脳梅祿媒錄蘆脰梅露爐攏盧露脭驢脝脩脨脫脨脜簍潞帽碌脛脨脣脠隴攏祿
6. 戮脽鹵賂露脌脕壟驢脝脩脨鹿隴脳梅脛脺脕婁脫毛脕錄潞脙碌脛驢脝錄錄脫壟脦脛露脕脨麓脛脺脕婁隆攏

虜漏脢驢潞貿(mào)脡錨脟毛虜脛脕脧攏潞脧錨脧賂賂枚脠脣錄貌脌煤攏盧脩脨戮驢戮顱脌煤脳脺陸謾碌脠脰隴脙梅鹿隴脳梅潞脥驢脝脩脨脛脺脕婁碌脛碌莽脳脫擄忙脦脛錄鎂隆攏


賂脷脦祿麓媒脫枚

1攏盧賂脷脦祿麓媒脫枚擄麓脮脮脟氓祿陋麓貿(mào)脩摟脧脿鹿脴鹿忙露簍脰麓脨脨隆攏驢脦脤芒脳茅陸蘆賂霉戮脻鹿隴脳梅脟茅驢枚脤謾鹿漏脪祿露簍脡煤祿卯虜鹿脰煤潞脥錄簍脨摟陸鹵脌酶隆攏脛錨脨陸虜?shù)撀得嵜撁?5脥貌隆攏脕鉚脥芒攏盧賂霉戮脻鹵戮碌樓脦祿脧脿鹿脴鹿忙露簍攏盧虜漏脢驢潞貿(mào)脪脭碌脷脪祿脳梅脮脽隆壟脟氓祿陋麓貿(mào)脩摟脦陋碌脷脪祿碌樓脦祿路壟鹵鉚賂脽脣廬脝陸脩摟脢玫脝脷驢爐驢脡祿帽碌脙脫脨路脟魯攏脫脨戮潞脮霉脕婁碌脛錄簍脨摟陸鹵脌酶攏簍https://postdoctor.tsinghua.edu.cn/攏漏攏祿
2攏盧祿媒錄蘆脰摟魯脰脤玫錄鎂脫脜脨茫脮脽脡錨脟毛鹿煤錄脪隆擄虜漏脨脗錄脝祿廬隆鹵隆壟脟氓祿陋麓貿(mào)脩摟隆擄脣廬脛戮脩摟脮脽隆鹵錄脝祿廬
攏簍https://postdoctor.tsinghua.edu.cn/thu/index.htm攏漏脪脭錄擄脝盲脣沒露脿脰脰脟氓祿陋麓貿(mào)脩摟虜漏脢驢潞貿(mào)脰摟魯脰錄脝祿廬隆攏脳脢脰煤露卯露脠脳卯賂脽40脥貌脭陋攏盧脕鉚脫脨露脿脧卯賂攏脌沒鹵攏脮脧攏祿
3攏盧脟氓祿陋麓貿(mào)脩摟脤謾鹿漏驢脡脳芒脳隆碌脛虜漏脢驢潞貿(mào)鹿蘆脭壟攏簍祿貌陸脧脦陋脫脜脭陸碌脛脳芒路驢虜鹿脤霉攏漏虜壟陸芒戮枚脳脫脜廬脠毛脭擄隆壟脠毛脩摟攏祿脧鉚脢脺脟氓祿陋麓貿(mào)脩摟陸脤脰擄鹿隴脡莽祿謾鹵攏脧脮隆壟脳隆路驢鹿蘆祿媒陸冒碌脠麓媒脫枚攏祿脧鉚脢脺脠?zhí)J鹿煤虜漏鹿脺祿謾鹿脴脫脷魯枚脮戮虜漏脢驢潞貿(mào)祿摟驢脷脟簍脪脝錄擄錄脪脢么祿摟驢脷脣忙脟簍碌脠脮鎂虜脽攏祿
4攏盧脰摟魯脰虜漏脢驢潞貿(mào)祿霉陸冒潞脥脳脭脠祿驢脝脩摟祿霉陸冒脡錨脟毛攏祿露脭鹵鉚脧脰魯枚陸脧脟驢驢脝脩脨脟鹵脕婁虜壟脫脨脪芒錄脤脨酶麓脫脢脗驢脝脩脨鹿隴脳梅碌脛虜漏脢驢潞貿(mào)攏盧鹿脴脳壟虜壟祿媒錄蘆脨顱脰煤脝盲驢脝脩脨脰擄脪碌路壟脮鹿潞脥鹿忙祿廬隆攏

脡錨脟毛路陸脢陸
脟毛陸蘆脧脿鹿脴碌莽脳脫擄忙pdf脡錨脟毛虜脛脕脧路壟脣脥脰脕lingchu@mail.tsinghua.edu.cn隆攏脫脢錄鎂鹵錨脤芒脟毛脳壟脙梅隆擄脫婁脝賂虜漏脢驢潞貿(mào)+脨脮脙沒隆鹵隆攏潞脧脢脢脮脽攏盧陸蘆戮隆驢矛脕陋脧碌擄虜脜脜脙忙脢脭攏盧擄矛脌鉚虜漏脢驢潞貿(mào)陸酶脮戮脢脰脨酶祿貌脟漏露漏脌脥露爐潞脧脥盧隆攏

脮脨脝賂脢鹵脧脼
魯隴脝脷脫脨脨摟

麓煤鹵鉚脗脹脦脛

1.        M. J. Bond†, L. Chu†, D. A. Nalawansha, K. Li, C. Crews Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs. ACS Cent. Sci. 2020, 6, 1367-1375. (†co-first author)
2.        L. Chu, J. Tyson, J. Shaw, F. Rivera-Molina, A. Koleske, A. Schepartz, and D. Toomre Two-color nanoscopy of organelles for extended times with HIDE probes. Nat. Comm. 2020, 11, 4271.
3.        Z. Jin†, L. Chu†, Y. Chen, and J.-Q. Yu Pd-Catalyzed Remote meta-C簍CH Functionalization of Phenylacetic Acids Using a Pyridine Template. Org. Lett. 2018, 20, 425-428. (†co-first author)
4.        L. Chu, M. Shang, K. Tanaka, Q. Chen, N. Pissarnitski, E. Streckfuss, and J.-Q. Yu Remote meta-C簍CH activation using a pyridine-based template: achieving site-selectivity via the recognition of distance and geometry. ACS Cent. Sci. 2015, 1, 394-399.
5.        L. Chu, K. -J. Xiao, J.-Q. Yu Room-temperature enantioselective C簍CH iodination via kinetic resolution. Science 2014, 346, 451-455.
6.        L. Chu, X. -C. Wang, C. E. Moore, A. L. Rheingold, J.-Q. Yu Pd-catalyzed enantioselective C簍CH Iodination: asymmetric synthesis of chiral diarylmethylamines. J. Am. Chem. Soc. 2013, 135, 16344-16347. 返回小木蟲查看更多