Add 165g of L-phenylalanine to 2 liters of ethanol, add 243ml of aqueous formaldehyde solution (37%), slowly at 0 degreesAdd a solution of 114 g of sodium borohydride dissolved in 1 liter of ethanol, control the temperature below 20 degrees, add dropwise after 2 hours, and stir for 8 hours.The reaction was detected to be complete. The pH was adjusted to 4-5 with 6N hydrochloric acid, the ethanol was concentrated, and the residue was extracted with ethyl acetate.Dried and concentrated to obtain 180g of product,The content is 98%, and the yield is 93.2%,
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合成路線:
1.通過甲醛和L-苯丙氨酸合成N,N-二甲基-L-苯丙氨酸,收率約91%;
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Add 165g of L-phenylalanine to 2 liters of ethanol, add 243ml of aqueous formaldehyde solution (37%), slowly at 0 degreesAdd a solution of 114 g of sodium borohydride dissolved in 1 liter of ethanol, control the temperature below 20 degrees, add dropwise after 2 hours, and stir for 8 hours.The reaction was detected to be complete. The pH was adjusted to 4-5 with 6N hydrochloric acid, the ethanol was concentrated, and the residue was extracted with ethyl acetate.Dried and concentrated to obtain 180g of product,The content is 98%, and the yield is 93.2%,
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