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小毛毛311

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理化定性、定量方法就有。

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11樓2014-06-06 17:12:45

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wunanxing-

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10樓: Originally posted by 小木山 at 2014-06-06 15:07:16
離子色譜應該可以

恩，謝謝，回頭試試，成了回來散金幣

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12樓2014-06-06 17:38:38

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786486898

13樓2014-06-06 17:39:33

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RXMCDM

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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感謝參與，應助指數(shù) +1
wunanxing-: 金幣+20, ★有幫助 2014-06-09 09:54:46

Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate.
Collins MD1, Scott WJ, Miller SJ, Evans DA, Nau H.
Author information 1Institute of Toxicology and Embryopharmacology, Free University Berlin, Germany.
Abstract
A mouse model for the induction of exencephaly with sodium (+/-)-2-ethylhexanoate has been developed using multiple administration regimes. With three consecutive administrations at one-half-day intervals, the most sensitive time to induce exencephaly was Gestational Days 8-9. Using the racemic substance it was determined that the SWV strain was more sensitive to the induction of exencephaly than the C57BL/6NCrlBR strain. The enantiomers of 2-ethylhexanoic acid were separated via preparative HPLC to greater than 99.8% optical purity, and greater than 99% purity according to a gas chromatographic analysis. It was demonstrated that the (R)-enantiomer is a more potent teratogen than the (S)-enantiomer for the induction of exencephaly as well as malformations of other organ systems. Pharmacokinetic analyses for each of the enantiomers were performed in maternal plasma, maternal muscle, and embryo. The pharmacokinetics showed that the peak concentration (Cmax) for both enantiomers in the three compartments was approximately equivalent and was attained within 15 min following the third administration. The area under the concentration versus time curve values for the two enantiomers were approximately 10% higher for the (R)-antipode because of a slightly slower elimination of this compound. There was negligible (or no) racemization of the two enantiomers in the biological samples. The results suggest that teratologic differences in the enantiomers of sodium 2-ethylhexanoate are not due to differences in the concentrations of these antipodes in the embryo, but more likely result from the specific interaction of the enantiomers with chiral molecules in the embryo.

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？

14樓2014-06-06 17:45:23

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wangchun8ha

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感謝參與，應助指數(shù) +1

對不起啊，不太了解，建議問問你們師兄師姐或者搜關鍵詞，看看相關文獻

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要做就做最好！

15樓2014-06-06 17:58:02

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wunanxing-

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15樓: Originally posted by wangchun8ha at 2014-06-06 17:58:02
對不起啊，不太了解，建議問問你們師兄師姐或者搜關鍵詞，看看相關文獻

我是第一個吃螃蟹的，和師兄師姐研究的完全不一樣

，不管怎么說謝了

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16樓2014-06-07 10:36:32

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wunanxing-

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11樓: Originally posted by 小毛毛311 at 2014-06-06 17:12:45
理化定性、定量方法就有。

我查了查，還是不懂

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17樓2014-06-07 10:37:57

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wunanxing-

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13樓: Originally posted by 786486898 at 2014-06-06 17:39:33

18樓2014-06-07 10:45:35

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wunanxing-

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費姚永芬: 不可求助文獻奧 2014-06-07 16:58:24

引用回帖:

14樓: Originally posted by RXMCDM at 2014-06-06 17:45:23
Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate.
Collins MD1, Scott WJ, Miller SJ, Evans DA, Nau H.
Author information 1Institute of Toxicology and Embryopharma ...

先謝謝啦，摘要里邊只說了通過HPLC和氣相色譜檢測異辛酸純度，沒有說怎么檢測異辛酸鈉啊，有文獻全文么？

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19樓2014-06-07 11:04:39

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亮亮xmlgxy

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像向陽花一樣綻放

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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
wunanxing-: 金幣+20, ★有幫助 2014-06-09 09:55:05

異辛酸鈉，相應的文獻感覺比較少啊
http://www.sciencedirect.com/sci ... i/S0040403998015469
http://www.sciencedirect.com/science/article/pii/0041008X9290195X

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陽光打在你的臉上，溫暖留在我們心頭

20樓2014-06-08 20:04:44

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