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本帖產(chǎn)生 1 個(gè) 翻譯EPI ，點(diǎn)擊這里進(jìn)行查看

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7樓: Originally posted by Rio2016 at 2013-04-21 22:00:15
本文的實(shí)驗(yàn)?zāi)康模海?）考察影響非靶向性聚乳酸（PLA）載藥納米粒制備的工藝因素，并對(duì)處方進(jìn)行工藝優(yōu)化，制備出粒徑較小、載藥率和包封率較高的PLA載藥納米粒；（2）探索不同反應(yīng)條件對(duì)肺靶向配體分子葉酸（FA）和透 ...

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11樓2013-04-22 08:49:33

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(3) 考察不同PH值（PH=4.3、PH=5.6和PH=7.4）、不同載藥率（9.53%、17.48%和26.37%）以及偶聯(lián)配體對(duì)納米粒釋藥性能的影響，并模擬人體內(nèi)部環(huán)境進(jìn)行釋藥行為的研究，分析每個(gè)階段的釋藥機(jī)理，擬合五種常見(jiàn)藥物模型的曲線方程并選擇最佳釋藥模型。

(3) the influence of pH values (pH = 4.3, 5.6 and 7.4), drug loading rates (9.53%, 17.48%, and 26.37%), and the of coupling ligands on the drug release properties of nanoparticles were studied, and the internal environment release behavior of body was simulated, the release mechanism in different stage was analysed, the best drug delivery model was selected through fitting the curve equation model of five kinds of common drugs.

實(shí)驗(yàn)結(jié)果：（1）通過(guò)單因素考察和正交試驗(yàn)設(shè)計(jì)確定了制備三種載藥納米粒的最佳制備工藝，在最佳制備條件下制得的載藥納米粒載藥率和包封率分別為26.9%，66.5%；27.4%，67.2%和30.3%，73.6%。納米粒表面光滑圓整、分散性好，平均粒徑分別為110nm、117nm和125nm，且粒徑分布范圍較窄；

Results: (1) the best fabrication process of three kinds of drug-loaded nanoparticles were determined through the investigation of single factor and orthogonal design, drug loading rates of the three kinds of drug-loaded nanoparticles obtained in the optimal preparation process were 26.9%, 27.4%, and 30.3%, respectively, while the encapsulation efficiency of that were 66.5%, 67.2%, and 73.6%. The average diameter of obtained nanoparticles were 110nm, 117nm, and 125 nm, respectively, with smooth and rounded morphology, good dispersion, and narrow particle size distribution.

(2) 用紅外光譜（IR）表征納米粒表面分子基團(tuán)的變化，表明FA和HA分別通過(guò)酰胺鍵作用成功的偶聯(lián)到了納米粒表面。確定了FA和HA的最佳偶聯(lián)工藝，在最佳偶聯(lián)反應(yīng)條件下FA和HA的偶聯(lián)量分別為0.0237×10-3mol/g和0.0178×10-6mol/g。粒徑分析表明FA偶聯(lián)前后納米粒粒徑基本無(wú)變化，HA（Mr=300000）偶聯(lián)后粒徑由122.2nm增長(zhǎng)到131.3nm，表明大分子量的HA對(duì)粒徑變化影響較大。通過(guò)放大不同倍數(shù)的SEM照片可看出配體偶聯(lián)后納米粒分布均勻，分散性較好；

The change of molecular groups on nanoparticle surface were characterized by infrared spectroscopy (IR), the study results indicated that HA and FA groups were successfully coupled to the nanoparticles with the amide bonds. The coupling amount of FA and HA under the optimal process, which was decided in our experiment, were 0.0237 × 10-3mol/g and 0.0178 × 10 6 mol/g. The results of particle size analysis showed that the size of nanoparticles were same before and after the FA coupling, while the particles size increased from 122.2nm to 131.3nm with the HA(Mr=300000) coupling, which indicated that the high molecular weight HA has a great impact on particle size. The SEM photographs with different magnification showed the uniform distribution and good dispersion of ligand coupled nanoparticle

（3）納米粒釋藥速率和累積釋藥量順序?yàn)镻H=4.3＞PH=5.6＞PH=7.4，且在一定PH范圍內(nèi)酸性越強(qiáng)釋藥速率和累計(jì)釋放量越高，高載藥率納米粒在相同環(huán)境下的釋藥速率高于中、低載藥率納米粒，F(xiàn)A偶聯(lián)后對(duì)納米粒釋藥性能基本無(wú)影響，大分子的HA偶聯(lián)到納米粒表面后釋藥速率明顯降低。靶向PLA載藥納米粒模擬體內(nèi)環(huán)境釋藥表現(xiàn)出良好的緩釋效果，擬合的FA/HA-PLA載藥納米粒的釋藥模型分別為InIn(1/(1-Q))=0.04633Int-1.03562和1-Q1/3=-0.01368t+1.04726。

Drug release rate and the cumulative amount of drug release of nanoparticles decreased with the increasing pH values(4.3, 5.6, and 7.4), and the stronger acidity within a certain pH range leads to a higher release rate and cumulative release, release rate of high drug loading nanoparticles is higher than that in middle and low drug loading nanoparticles in the same conditions, the influence of FA coupling on the drug release properties of nanoparticles was little, drug release rate was significantly reduced after macromolecular HA coupled to the surface of the nanoparticles. targeting PLA drug-loaded nanoparticles exhibited good controlled-release effect in simulated environment of body, the fitted FA and HA-PLA drug release model of the drug-loaded nanoparticles were ININ (1 / (1-Q)) = 0.04633 Int-1.03562 and 1-Q1 / 3 =-0.01368t +1.04726, respectively.

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12樓2013-04-22 09:18:51

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10樓: Originally posted by yerufeng20 at 2013-04-22 08:46:56
謝謝了啊，我漢語(yǔ)沒(méi)學(xué)好，英語(yǔ)學(xué)的就更差了，唉，很奇怪的，對(duì)語(yǔ)言沒(méi)感覺(jué)，麻煩您再給我看看剩下的吧，EPI只能給一個(gè)人嗎？您幫我翻譯的多，呵呵，先給您吧...

已翻，水平一般，僅供樓主參考

版主，掛牌掛的不少啊，把那牌子給我搞一個(gè)唄，呵呵~~~

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13樓2013-04-22 09:22:10

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13樓: Originally posted by huangzx1314 at 2013-04-22 09:22:10
已翻，水平一般，僅供樓主參考

版主，掛牌掛的不少啊，把那牌子給我搞一個(gè)唄，呵呵~~~

...

牌牌沒(méi)用啊，真羨慕你的英語(yǔ)水平啊

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14樓2013-04-22 09:33:31

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14樓: Originally posted by 眼淚成詩(shī) at 2013-04-22 09:33:31

牌牌沒(méi)用啊，真羨慕你的英語(yǔ)水平啊

...

其實(shí)我的英語(yǔ)稀爛啊，呵呵，還請(qǐng)樓主自己在好好看看

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15樓2013-04-22 09:37:25

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15樓: Originally posted by huangzx1314 at 2013-04-22 09:37:25
其實(shí)我的英語(yǔ)稀爛啊，呵呵，還請(qǐng)樓主自己在好好看看

~~...

好的，謝謝了

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16樓2013-04-22 09:40:43

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Rio2016

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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
眼淚成詩(shī): 金幣+50, ★★★★★最佳答案, 謝謝你，可以幫我看看這個(gè)嗎（http://emuch.net/bbs/viewthread.php?tid=5919688）？謝謝 2013-05-22 07:47:52

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11樓: Originally posted by 眼淚成詩(shī) at 2013-04-22 08:49:33
您沒(méi)選擇應(yīng)助回帖啊？

...

有么

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17樓2013-04-22 09:46:07

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yerufeng20

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17樓: Originally posted by Rio2016 at 2013-04-22 09:46:07
有么

當(dāng)初只回復(fù)了目的部分可能太匆忙點(diǎn)錯(cuò)了...

在回復(fù)一下吧，給50bb，略表謝意吧，下面那位翻譯的多就把翻譯EPI給他了，還望見(jiàn)諒哈

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佇倚危樓風(fēng)細(xì)細(xì)，望極春愁，黯黯生天際。草色煙光殘照里，無(wú)言誰(shuí)會(huì)憑闌意。擬把疏狂圖一醉。對(duì)酒當(dāng)歌，強(qiáng)樂(lè)還無(wú)味。衣帶漸寬終不悔，為伊消得人憔悴。

18樓2013-04-22 10:52:28

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17樓: Originally posted by Rio2016 at 2013-04-22 09:46:07
有么

當(dāng)初只回復(fù)了目的部分可能太匆忙點(diǎn)錯(cuò)了...

可以幫我看看這個(gè)嗎？http://www.gaoyang168.com/bbs/viewthread.php?tid=5919688
謝謝

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19樓2013-05-22 07:48:18

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