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| 本帖產(chǎn)生 1 個 翻譯EPI ，點擊這里進(jìn)行查看 | |||
zhouwenliWLW木蟲 (小有名氣)
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[求助]
請幫幫忙翻譯一下，這幾天急用，謝謝！
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| 目的 通過實驗確定PNG的處方和制備工藝。方法 1)考察甘露醇及氯化鈉用量，優(yōu)選凍干粉針最佳處方。2)考察活性炭用量及其對主要成分含量的影響。3)考察pH值調(diào)節(jié)劑及注射液配制的pH值范圍，確定制備工藝。結(jié)果 PNG凍干制劑工藝中加入10%甘露醇和10%氯化鈉時外觀最好，且無塌陷、無裂紋、水分最低，活性炭用量為3%時既達(dá)到了除熱原的目的又不影響PNG含量。結(jié)論 PNG凍干制劑的處方合理，制備工藝可行。 |
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genhunter
至尊木蟲 (著名寫手)
- 翻譯EPI: 387
- 應(yīng)助: 259 (大學(xué)生)
- 金幣: 9757.4
- 散金: 10
- 紅花: 60
- 帖子: 2484
- 在線: 1793小時
- 蟲號: 2558361
- 注冊: 2013-07-22
- 專業(yè): 腫瘤化學(xué)藥物治療
【答案】應(yīng)助回帖
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zhouwenliWLW: 金幣+30, 翻譯EPI+1, ★★★很有幫助, 謝謝你！ 2016-03-19 10:22:40
zhouwenliWLW: 金幣+30, 翻譯EPI+1, ★★★很有幫助, 謝謝你！ 2016-03-19 10:22:40
| Objectives: To experimentally determine the formulation for PNG and manufacturing process. Method: We evaluated 1) the effects of the dosages of mannitol and sodium chloride on the lyophilization process, and optimized the composition of the lyophilized powder. 2) effects of the dosage of activated carbon and its influence on the contents of main ingredients. 3) the type of buffering agent used for the adjustment of pH and the range of pH for the finished injectile, and based on these factors, we finalized the manufacturing process. The best appearance of the freeze-dried cake of PNG was obtained with 10% mannitol and 10% sodium chloride in the formulation, and finished products had no collapses or cracks, had the lowest water contents; the chosen dosage for activated carbon is 3%, which allows to remove pyrogen and not to affect the contents of PNG. Conclusion: The formulation for the PNG lyophilized preparation is rational and the processing is feasible |
2樓2016-03-19 10:09:10
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