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| 本帖產(chǎn)生 1 個 翻譯EPI ，點(diǎn)擊這里進(jìn)行查看 | ||
[求助]
求翻譯，求幫忙。。。。
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Because known indolotryptolines are potent human cell line toxins, previously unknown compounds 5–7, as well as cladoniamide A (3) as a control, were tested for cytotoxicity against HCT-116 human colon carcinoma cancer cells. The IC 50 s observed for compounds 3 and 5–7 were 40.4 nM, 25.8 μM, 11.6 nM, and 8.4 nM, respectively (Fig. 3D). In this series of closely related natural products, lazarimide A (7) exhibits the most potent cytotoxicity against human cells. Activation of the Lzr gene cluster demonstrates the utility of our platform toward characterizing new biomedically relevant metabolites through the activation not only of silent but also of naturally dead biosynthetic gene clusters. |
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【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
bxzc123: 金幣+35, 翻譯EPI+1 2016-03-29 19:25:16
bxzc123(RXMCDM代發(fā)): 金幣+10 2016-04-09 19:41:51
bxzc123: 金幣+35, 翻譯EPI+1 2016-03-29 19:25:16
bxzc123(RXMCDM代發(fā)): 金幣+10 2016-04-09 19:41:51
| 因?yàn)椤ひ阎猧ndolotryptolines是人類細(xì)胞系的毒素，未知化合物5-7，以及cladoniamide A（3）作為控制來檢測人類結(jié)腸癌癌細(xì)胞HCT-116的細(xì)胞毒性。IC50年代觀察的化合物3和5-7是40.4納米，25.8微米，11.6納米和8.4納米如（圖3D）。這個系列與天然產(chǎn)品密切相關(guān)，lazarimide(7)展示了對人類細(xì)胞最強(qiáng)有力的細(xì)胞毒性。激活的Lzr基因簇演示了我們平臺對描述新的生物醫(yī)學(xué)相關(guān)代謝物的激活的效用，不僅僅是悄無聲息也是生物合成基因簇的自然死亡。ps：幾個醫(yī)學(xué)專用次查不到意思，翻譯的可能不精準(zhǔn) |
2樓2016-03-29 10:57:11
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