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ouxueling新蟲 (初入文壇)
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[求助]
請(qǐng)大家?guī)兔纯磳徃迦艘庖?jiàn) 已有1人參與
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大家好，本人兩月前投稿Scientific Reports，雖然使用的是未報(bào)到過(guò)的新方法，但因?yàn)樽龅陌咐容^少（才7個(gè)家系，但已經(jīng)用了10幾萬(wàn)了），因此也不敢投太好的雜志，先投Scientific Reports試試。前天收到Decision Letter，是Major Revison。但看了一下Reviewer #1的意見(jiàn)，他明顯也是覺(jué)得樣品量小。但我有點(diǎn)看不太明白，他的意思是讓我擴(kuò)大樣品量再投稿呢，還是說(shuō)在未來(lái)進(jìn)一步的研究中要增加樣品量來(lái)驗(yàn)證這個(gè)方法的準(zhǔn)確性呢？擴(kuò)大樣品量再投是不可能的了，經(jīng)費(fèi)已經(jīng)沒(méi)剩多少了，況且只有四周的修回時(shí)間。大家?guī)臀铱纯矗瑢徃迦说降资鞘裁匆馑�？要補(bǔ)做實(shí)驗(yàn)嗎？如果我確實(shí)不想補(bǔ)做的話，我該如何回答審稿人的意見(jiàn)？ Reviewer #1 (Technical Comments to the Author): Additional experiments and data are definitely needed to support conclusions drawn from this study. All findings need to reflect the limitation of the small sample size, which currently it does not. With such a small sample size, the scale of this study needs to be amplified in order to get a clearer picture of the test’s validity and reliability. Also, as the authors noted, further analysis must be conducted to assess if early gestation samples would provide sufficient cfDNA samples to yield results distinguishable from sequencing noise. This is a major issue for the feasibility of using this testing technology. Therefore, further research must be conducted to test the solutions to this problem that the authors proposed. Reviewer #1 (Remarks to the Author): Besides a couple of minor syntactic errors, this article is very well written. The authors clearly present background information pertaining to the current state of paternity testing and prenatal testing technology, and then present a compelling case for the implementation of their non-invasive paternity testing. However, the small sample size is very concerning. This could be a pilot study at best, and much more work needs to be done before any conclusions may be drawn. |
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【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★
感謝參與，應(yīng)助指數(shù) +1
paperhunter: 金幣+1, 鼓勵(lì)交流 2016-09-30 23:51:11
ouxueling: 金幣+5, ★★★很有幫助 2016-10-01 20:00:30
感謝參與，應(yīng)助指數(shù) +1
paperhunter: 金幣+1, 鼓勵(lì)交流 2016-09-30 23:51:11
ouxueling: 金幣+5, ★★★很有幫助 2016-10-01 20:00:30
| 修回時(shí)間可以申請(qǐng)延長(zhǎng)，但是審稿人的意見(jiàn)不搞定，覺(jué)得很難收?qǐng)觥?further research must be conducted to test the solutions to this problem that the authors proposed，審稿人用must這個(gè)語(yǔ)氣相當(dāng)強(qiáng)烈，覺(jué)得不補(bǔ)做很難過(guò)關(guān) |
2樓2016-09-30 20:28:24
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