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Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma 雜志社是Latin American Journal of Pharmacy 非常感謝 @阿努 發(fā)自小木蟲Android客戶端 |
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lazy錦溪
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【答案】應(yīng)助回帖
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感謝參與，應(yīng)助指數(shù) +1
vwkiller: 金幣+20, ★★★★★最佳答案 2016-12-05 14:53:23
心靜_依然: LS-EPI+1, 感謝應(yīng)助 2016-12-05 18:24:09
感謝參與，應(yīng)助指數(shù) +1
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心靜_依然: LS-EPI+1, 感謝應(yīng)助 2016-12-05 18:24:09
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Validated UPLC-MS/MS Method for the Determination of Sunitinib in Rat Plasma 作者:Zhang, Y (Zhang, Yu)[ 1 ] ; Yuan, RR (Yuan, Rong-rong)[ 1 ] ; Zheng, XK (Zheng, Xiao-kang)[ 2 ] ; Hua, CL (Hua, Chang-lin)[ 2 ] ; Wang, YQ (Wang, Ya-qiang)[ 1 ] LATIN AMERICAN JOURNAL OF PHARMACY 卷: 35 期: 6 頁(yè): 1304-1308 出版年: 2016 查看期刊信息 摘要 In this study, a simple, rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method is described for determination of sunitinib in rat plasma samples using diazepam as the internal standard (IS) from pharmacokinetic assays. Sample preparation was accomplished through a simple protein precipitation with acetonitrile, and chromatographic separation was performed on an Acquity BEH C18 column (2.1 mm x 50 mm, 1.7 mu m) with gradient profile at a flow of 0.40 ml/min. The linearity of this method was found to be within the concentration range of 0.2-400 ng/mL for sunitinib in rat plasma. Only 3.0 min was needed for an analytical run. The method was applied to a pharmacokinetic study of sunitinib in rats. 關(guān)鍵詞 作者關(guān)鍵詞:sunitinib; UPLC-MS/MS; rat plasma; pharmacokinetics KeyWords Plus:TANDEM MASS-SPECTROMETRY; N-DESETHYL SUNITINIB; RENAL-CELL CARCINOMA; ACTIVE METABOLITE; TYROSINE KINASE; MOUSE PLASMA; QUANTIFICATION; INHIBITOR; QUANTITATION; SORAFENIB 作者信息 通訊作者地址: Wang, YQ (通訊作者) [顯示增強(qiáng)組織信息的名稱] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China. 地址: [顯示增強(qiáng)組織信息的名稱] [ 1 ] Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China [顯示增強(qiáng)組織信息的名稱] [ 2 ] Henan Univ Sci & Technol, Coll Med, Luoyang 471003, Peoples R China 電子郵件地址:kgwangyq@163.com 出版商 COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES, DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA 類別 / 分類 研究方向  harmacology & PharmacyWeb of Science 類別 harmacology & Pharmacy文獻(xiàn)信息 文獻(xiàn)類型:Article 語(yǔ)種:English 入藏號(hào): WOS:000384517000005 ISSN: 0326-2383 期刊信息 Impact Factor (影響因子): Journal Citation Reports® 其他信息 IDS 號(hào): DX6TW Web of Science 核心合集中的 "引用的參考文獻(xiàn)": 21 Web of Science 核心合集中的 "被引頻次": 0 |
2樓2016-12-05 12:13:38
lazy錦溪
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vwkiller3樓2016-12-05 12:13:56
4樓2016-12-05 14:54:30
lazy錦溪
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