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lvp490銅蟲 (初入文壇)
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2 Funded PhD Opportunities in Cold Plasma and Food in Ireland
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2 Funded PhD positions in Dublin Institute of Technology, Ireland Project: Cold Plasma Innovations for Food Safety and Sustainability This Project is based in the Plasma Research Group at Dublin Institute of Technology in partnership with Queens University Belfast School of Pharmacy and the Global Institute for Food Security. PhD 1: Allergen Control Project Description : The EnvironSafe project will understand and develop atmospheric cold plasma based approaches to control and prevent the ingress of key risk factors to the food chain leading to enhanced food safety and sustainability. Cold Plasma based approaches have the potential to replace biocides and antibiotics or to enhance activity of known antimicrobial agents against microbiological challenges. Additionally, we will investigate Cold Plasma interactions for the increasingly important area of allergen control. Cold Plasma processing of known food allergens may reduce the allergenicity potential in food environments to provide scope for innovative production practices and product lines. These programs of research will focus on developing a mechanistic understanding of how ACP interacts with biological and food derived allergen risks. Iterative understanding of the biological and chemical responses will inform the development of novel cold plasma technologies, using both dry and liquid forms as means of delivery. A postgraduate position is available to investigate cold plasma interactions with food based allergens. Thermostable allergens (from cereals) cannot be reduced effectively bycurrent processing technologies. In peanuts, Ara h1 (600-700 kDa) and Ara h2 (20 kDa) protein are considered as the main allergens among 17 discovered proteins with allergenic capacity. Casein is a dairy derived thermostable allergen. Wheat contains many allergenic components such as gluten, glutelins, prolamins, albumin and globulin. Gluten is the main concern for both food allergy and intolerance, which is heat sensitive and is widely present in processed wheat products. Recent work indicates that ACP has potential as an allergen modification or decontamination step in food processing. This project will evaluate potential for allergen control, determine suitable modes of application for food processing environments, and examine the effects on immuno-reactivity. PhD 2: Biological Interactions with Cold Plasma The EnvironSafe project will understand and develop atmospheric cold plasma based approaches to control and prevent the ingress of key risk factors to the food chain leading to enhanced food safety and sustainability. Cold Plasma based approaches have the potential to replace biocides and antibiotics or to enhance activity of known antimicrobial agents against microbiological challenges. Additionally, we will investigate Cold Plasma interactions for the increasingly important area of allergen control. Cold Plasma processing of known food allergens may reduce the allergenicity potential in food environments to provide scope for innovative production practices and product lines. These programs of research will focus on developing a mechanistic understanding of how ACP interacts with biological and food derived allergen risks. Iterative understanding of the biological and chemical responses will inform the development of novel cold plasma technologies, using both dry and liquid forms as means of delivery. A postgraduate position is available to investigate the biological interactions and the safety of cold plasma for technology adoption. Employing cold plasma technologies to address food and environmental contamination issues not only requires adequate performance in terms of reduction of microbial and chemical challenges but will also have to guarantee eco-toxicological and consumer safety. Aqueous plasma-treated solutions have been shown to retain antimicrobial activity over extended periods of time after the treatment and possess cytotoxic effects on mammalian cells. Therefore potential adverse effects of plasma-treated food substances or contact surfaces and the underlying mechanisms of action will be investigated. Furthermore the toxicological profile of break-down products of chemical and biological contaminants degraded by plasma is required to determine not only acute but also the long-term safety of the technology. Cytotoxicity, genotoxicity and ecotoxicity will be evaluated to assess and ensure the lifecycle safety of the technology for the user, consumer and environment. Comprehensive mechanistic understanding of biological interactions will be achieved using inactivation studies, metabolic activity assays, material science, microscopy (AFM, SEM, CLSM), as well as genomics to evaluate potential resistance or virulence factors. Chemical interactions and degradations will be elucidated using Mass spectroscopy, FTIR, NMR in addition to simple dye reduction assays when appropriate. Biological and toxicological safety evaluation will comprise bacterial, mammalian and ecotoxicity and mutagenicity assays to ensure technology advances and mechanistic insights gained can be safely harnessed. Funding Notes Science Foundation Ireland Fees: ?4,500 per annum Stipend: ?18,500 per annum Eligibility Requirements: Minimum of 2.1 in level 8 B. Sc in Biology, Biochemistry, Food or Environmental Degree or B. Chem Eng. Previous research experience desirable. https://www.findaphd.com/search/ProjectDetails.aspx?PJID=85367 https://www.findaphd.com/search/ProjectDetails.aspx?PJID=85378 |
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