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【求助】指點一下藥物釋放模擬
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有哪位高手可以發(fā)點指點藥物釋放模擬的推導過程的文章、 公式、方法等的東西給我嗎？比如說應用Fick 1 ,Fick 2，Higuchi定律來對藥物的釋放進行模擬的方法等。 即通過數(shù)學的方法，對藥物的釋放進行模擬，從而達到預測藥物釋的目的，目前主要用到的方法有Fick1 Fick2 Higuchi定律等幾種方法，望各大蝦能發(fā)點經(jīng)典的文章予以指導。 [ Last edited by wgcui on 2009-2-23 at 19:39 ] |
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wgcui(金幣+1,VIP+0):謝謝討論 2-24 15:59
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Modeling the Loading and Unloading of Drugs into Nanotubes Small，2009，Volume 5 Issue 3, Pages 300 - 308 One of the most promising applications of nanotechnology is that of drug delivery, and in particular the targeted delivery of drugs using nanotubes. Functionalized nanotubes might be able to target specific cells, become ingested, and then release their contents in response to a chemical trigger. This will have significant implications for the future treatment of patients, particularly those suffering from cancer, for whom presently the nonspecific nature of chemotherapy often kills healthy normal cells. Research to date has largely been through experiments investigating toxicity, biocompatibility, solubility, functionalization, and cellular uptake. More recently, the loading and unloading of molecular cargo has gained momentum from both experimental and theoretical investigations. This Review focuses on the loading and unloading of molecular cargo and highlights recent theoretical investigations, which to date have received very little attention in the review literature. The development of nanotube drug-delivery capsules is of vital concern for the improvement of medical treatment, and mathematical modeling tends to facilitate such development and provides a quicker route to applications of the technology. This Review highlights the latest progress in terms of theoretical investigations and provides a focus for the development of the next generation of medical therapeutics. |
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UMN 制藥系的大牛Ronald A. Siegel 就是專門做藥物釋放模型的優(yōu)化的，你可以去看看他的文章 給你個鏈接吧 http://www.pharmacy.umn.edu/faculty/siegel_ronald/home.html |
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