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dentist_fuyf金蟲 (小有名氣)
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| Zhi Yang, Hao Gu, Gang Sha, et al. TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in Vitro[J]. ACS Applied Materials& Interfaces 2018, 10:41155−41166 |
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入藏號: WOS:000452694100023 TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in Vitro 作者:Yang, Z (Yang, Zhi)[ 1,2,3 ] ; Gu, H (Gu, Hao)[ 1,2,3 ] ; Sha, G (Sha, Gang)[ 4 ] ; Lu, WJ (Lu, Weijie)[ 5 ] ; Yu, WA (Yu, Weigiang)[ 1,2,3 ] ; Zhang, WJ (Zhang, Wenjie)[ 1,2,3 ] ; Fu, YF (Fu, Yuanfei)[ 1,2,3 ] ; Wang, KS (Wang, Kuaishe)[ 6 ] ; Wang, LQ (Wang, Liqiang)[ 5 ] 查看 Web of Science ResearcherID 和 ORCID ACS APPLIED MATERIALS & INTERFACES 卷: 10 期: 48 頁: 41155-41166 DOI: 10.1021/acsami.8b16343 出版年: DEC 5 2018 文獻(xiàn)類型:Article 查看期刊影響力 摘要 Numerous antibacterial biomaterials have been developed, but a majority of them suffer from poor biocompatibility. With the purpose of reducing biomaterial-related infection and cytotoxicity, friction stir processing (FSP) was employed to embed silver nanoparticles (Ag NPs) in a Ti- 6A1-4V (TC4) substrate. Characterization using scanning electron microscopy, transmission electron microscopy, and three-dimensional atom probe tomography illustrates that NPs are distributed more homogeneously on the surface of TC4 as the groove depth increases, and silver-rich NPs with a size from 10 to 20 nm exist as metallic silver diffused into the substrate, where the silver content is 4.3-5.6%. Electrochemical impedance spectroscopy shows that both FSP and the addition of silver have positive effects on corrosion resistance. The modified samples effectively inhibit both Staphylococcus aureus and Escherichia coli strains and slightly reduce their adhesion while not displaying any cytotoxicity to bone mesenchymal stem cells in vitro. The antibacterial effect is independent of Ag-ion release and is likely due to the number of embedded silver NPs on the surface, which directly contact and subsequently destroy the cell membrane. Our study shows that the TC4/Ag metal matrix nanocomposite is a potential infection-related biomaterial and that embedding Ag NPs tightly on a biomaterial surface is an effective strategy for striking a balance between the antibacterial effect and biocompatibility, providing an innovative approach for accurately controlling the cytotoxicity of infection-related biomaterials. 關(guān)鍵詞 作者關(guān)鍵詞:metal matrix nanocomposites; friction stir processing; surface characterization; antibacterial property; cytotoxicity KeyWords Plus:SILVER NANOPARTICLES; BIOLOGICAL-PROPERTIES; CORROSION BEHAVIOR; INFECTION; COATINGS; BIOFILM; TITANIA; RESISTANCE; CATHETERS; MECHANISM 作者信息 通訊作者地址: Fu, YF (通訊作者) 顯示更多顯示較少 Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Dept Prosthodont,Sch Med, Shanghai 200011, Peoples R China. 通訊作者地址: Fu, YF (通訊作者) Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China. 通訊作者地址: Fu, YF (通訊作者) Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China. 通訊作者地址: Wang, LQ (通訊作者) 顯示更多顯示較少 Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China. 通訊作者地址: Wang, KS (通訊作者) 顯示更多顯示較少 Xian Univ Architecture & Technol, Sch Met Engn, Xian 710055, Shaanxi, Peoples R China. 地址: 顯示更多顯示較少 [ 1 ] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Dept Prosthodont,Sch Med, Shanghai 200011, Peoples R China [ 2 ] Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China [ 3 ] Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China 顯示更多顯示較少 [ 4 ] Nanjing Univ Sci & Technol, Herbert Gleiter Inst Nanosci, Nanjing 210094, Jiangsu, Peoples R China 顯示更多顯示較少 [ 5 ] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China 顯示更多顯示較少 [ 6 ] Xian Univ Architecture & Technol, Sch Met Engn, Xian 710055, Shaanxi, Peoples R China 電子郵件地址:fuyuanf@163.com; wangkuaishe888@126.com; wang_liqiang@sjtu.edu.cn 基金資助致謝 基金資助機(jī)構(gòu) 授權(quán)號 National Key R&D Program of China 2017YFC0840110 National Science Foundation 51831011 51674167 51504152 Medical Engineering Cross key Research Foundation of the Shanghai Jiao Tong University YG2017ZD06 查看基金資助信息 出版商 AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 期刊信息 Impact Factor (影響因子): Journal Citation Reports 類別 / 分類 研究方向:Science & Technology - Other Topics; Materials Science Web of Science 類別:Nanoscience & Nanotechnology; Materials Science, Multidisciplinary 文獻(xiàn)信息 語言:English 入藏號: WOS:000452694100023 PubMed ID: 30403843 ISSN: 1944-8244 其他信息 IDS 號: HD6XR Web of Science 核心合集中的 "引用的參考文獻(xiàn)": 67 Web of Science 核心合集中的 "被引頻次": 1 |
3樓2019-05-16 14:28:30
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