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dabobo_lee金蟲 (小有名氣)
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法國波爾多大學(xué)誠招2020年CSC公派化學(xué)博士
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·¨?ú?¨???à?ó?§institute european chemistry and biology ?¨IECB) Guichard ????×é???????????? ??????Design and synthesis of foldamer-based enzyme mimetics ?ò?é?? In Nature, folding and function of biopolymers, such as proteins or nucleic acids, are two closely related notions that lead to an impressive variety of biological processes to occur. The design of bioinspired architectures to create innovative and functional nano(bio)systems in aqueous media has been a longstanding goal of the scientific community. Access to artificial enzymatic systems that would lead to efficient and new biocatalysts is of particular interest. Synthetic sequence-specific folded oligomers (also called ?°foldamers?±) possess interesting features to create self-assembled protein-like frameworks, with topologies similar to and beyond those of natural polypeptides. The ability of some foldamer backbones to form predictable and well-defined secondary structures, with helical folding properties being independent from the nature of the side-chain used (i.e. primary sequence), should facilitate morphological control at the nano-scale while displaying the desired functionalities. However, attempts to reproduce enzymatic activities using foldamer chemistry have remained limited thus far. Our group has pioneered the development and the structural characterization of aliphatic oligoureas as a new class of peptidomimetic foldamers during the last decade. The remarkable compatibility of their backbones with alpha-peptides has been recently demonstrated, highlighting thus the potential of interfacing natural peptides and ureabased backbones to create chimeric structures. Thus this PhD project aims to engineer de novo enzyme-like architectures using supramolecular assemblies of water-soluble peptide-oligourea chimera. ?ò???????ó?? ???????ú?????????????á?????¨±??°?¨NMR ,MS ?????? ????peptide ????????·?×????§???é??·????¤×÷???????????? ???è??·¨?????¨?? ???é???é???? CBMN-UMR 5248 Guichard ????×é???¨???à?ó?§??·¨?ú???§???¨CNRS??????×é????°ü?¨?¨???à?ó?§?°?¤??·¨?ú???§???????±?????????? ×é??????×??·?????????à???ú?????????ú???????ó??????·??§???????é?è±?????????°?????nice?? ?ê?é???????é???÷???? https://www.cbmn.u-bordeaux.fr/1 ... que.html#teamleader ?????¤?????§??·??? CV??cover letter ?? Morgane Pasco (m.pasco@iecb.u-bordeaux.fr, +33 5 4000 3015) ???????????????????ê?é?? FLYlbo |
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taebong
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dabobo_lee
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脠莽鹿沒脦脼路簍脫脢錄鎂脫脨脦脢脤芒攏盧驢脡脪脭路壟碌陸脦脪脮芒脌茂擄茂脛茫脳陋路壟攏潞boli224@hotmail.com [ 路壟脳脭脢脰祿煤擄忙 http://www.gaoyang168.com/3g ] |
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dabobo_lee
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7樓2019-12-04 03:24:58
dabobo_lee
金蟲 (小有名氣)
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虜脦脮脮CSC脳卯碌脥脫茂脩脭脪陋脟貿(mào)隆攏 虜簍露沒露脿麓貿(mào)脩摟脮芒鹵脽脦脛錄鎂脡脧脨麓碌脛脢脟脮芒攏潞Proof of Language proficiency in English English Test: TOEFL PbT (min 550), or TOEFL (ibT min 79) or IELTS (min 6.5) or TOEIC (min 685) or proof of CEFR level B2 in English or French隆攏 陸簍脪茅脙祿脫脨魯脡錄簍脰廬脟擄脪虜驢脡脪脭脧脠脕陋脧碌攏盧脠祿潞貿(mào)錄脤脨酶脳錄鹵賂驢錄脢脭隆攏脕鉚脥芒脥霉脛錨戮顱脩茅脫脨脳卯脰脮脦脼脫茂脩脭魯脡錄簍脪虜脥簍鹿媒碌脛脌媒脳脫 [ 路壟脳脭脢脰祿煤擄忙 http://www.gaoyang168.com/3g ] |
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dabobo_lee
金蟲 (小有名氣)
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