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【其他】zz德研研制出現(xiàn)場診斷微型實(shí)驗(yàn)室 化驗(yàn)只需30分鐘 已有1人參與
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http://www.analchem.cn/article.php?id=2625&optionid=75 據(jù)德國弗勞恩霍夫研究所網(wǎng)站報(bào)道，近日，該所科學(xué)家成功研制出一套微型實(shí)驗(yàn)室系統(tǒng)，可在現(xiàn)場進(jìn)行復(fù)雜的生物學(xué)化驗(yàn)，并在30分鐘內(nèi)得到結(jié)果。該系統(tǒng)有望在不久后投放市場。 隨著醫(yī)療技術(shù)的發(fā)展，許多疾病已可以通過實(shí)驗(yàn)室測試確診。然而，患者們不得不面對一個(gè)現(xiàn)實(shí)，即從樣本送去化驗(yàn)，到分析結(jié)果返回到醫(yī)生手中，需要等待很長時(shí)間，有時(shí)甚至是幾天到一兩周。而對很多疾病來說，快速診斷是治療取得成功的關(guān)鍵。不過未來，患者們也許只需在診室里等待很短的時(shí)間就可以拿到化驗(yàn)結(jié)果。這一切得益于弗勞恩霍夫7個(gè)研究所的研究人員共同合作的一個(gè)項(xiàng)目，他們?yōu)轶w外診斷開發(fā)了一個(gè)微型的模塊化平臺，針對如血液和唾液等不同的生物樣本，醫(yī)生可直接在診室進(jìn)行快速化驗(yàn)。 這一微型實(shí)驗(yàn)室的核心部件是一個(gè)可與不同傳感器匹配的一次性塑料測試盒。檢驗(yàn)時(shí)，醫(yī)生注入相應(yīng)的試劑，試劑中含有某些物質(zhì)，可證實(shí)樣本中是否含有對應(yīng)的抗原。針對不同的問題，檢測平臺提供不同的化驗(yàn)方法。執(zhí)行檢驗(yàn)時(shí)，醫(yī)生將相應(yīng)的樣本物質(zhì)注入測試盒，測試就會(huì)自動(dòng)進(jìn)行。研究人員表示，他們已經(jīng)優(yōu)化了化驗(yàn)過程，可在一個(gè)單獨(dú)的分析步驟中做到多達(dá)500項(xiàng)平行檢測反應(yīng)。因此，即便是復(fù)雜的分析，醫(yī)生也能很快得到化驗(yàn)結(jié)果。 由于該體外診斷平臺模塊化的設(shè)計(jì)原則非常靈活，研究人員認(rèn)為它幾乎適用于所有生物問題。將來，通過開發(fā)新的模塊，或許還能實(shí)現(xiàn)樣本在DNA層面的檢測。除去醫(yī)療市場外，該平臺還可應(yīng)用于食品分析或興奮劑檢測等領(lǐng)域。 http://www.sciencedaily.com/releases/2010/03/100319210434.htm ScienceDaily (Mar. 19, 2010) — Many illnesses can be reliably diagnosed through laboratory tests, but these in vitro analyses often use up valuable time. A system developed by Fraunhofer research scientists, which can carry out complex analyses on the spot, will soon be ready for the market. "We’ll just have to wait for the results of the laboratory test results." These words are familiar to many patients. It then usually takes several days for specimens to be sent to the laboratory and analyzed and for the doctor to receive the results. For many illnesses, however, a speedy diagnosis is crucial if the treatment is to be successful. In future, the patient might only have to sit in the waiting room for a few minutes until the results are ready. In a joint project, researchers from seven Fraunhofer institutes have developed a modular platform for in vitro diagnosis which enables various types of bioanalysis – of blood and saliva for example – to be conducted in the doctor’s surgery. "Thanks to its modular design our IVD platform is so flexible that it can be used for all possible bioanalytical tasks," states Dr. Eva Ehrentreich-Förster from the Fraunhofer Institute for Biomedical Engineering (IBMT) in Potsdam-Golm. The core element of the mini-laboratory is a disposable cartridge made of plastic which can be fitted with various types of sensor. For an analysis the doctor fills the cartridge with reagents – binding agents which indicate the presence of certain substances such as antigens in the specimen material. Various tests or assays are available for different types of analysis. To perform an assay, the doctor only has to place the relevant substances in the cartridge and the test then takes place automatically. "We have optimized the assays so that up to 500 assay reactions can be conducted in parallel in a single analysis step," explains Dr. Ehrentreich-Förster. Even in the case of complex analyses the doctor obtains a result within about 30 minutes. A new module on the reverse side of the cartridge also makes it possible to analyze the specimen material at DNA level. Once the cartridge has been prepared, the doctor places it in the measurement system. The results can be read out with either optical or electrochemical biosensors. The researchers have installed a readout window for both methods in the measurement system, which features a bypass through which the specimen is pumped. In addition to medical applications, Dr. Ehrentreich-Förster has other markets in her sights. "The IVD platform is also suitable for food analysis and doping checks." The mini-laboratory will soon be ready for the market. The scientists are presenting the IVD platform at the Analytica trade show in Munich from March 23 to 26. |
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