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cjnwlt金蟲 (小有名氣)
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[交流]
幫翻譯一篇生物制藥方面的英文摘要!
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Genetic adjuvants for DNA vaccines Abstract The relatively low efficacy of DNA vaccines in inducing immune responses,especially in large animal species and humans,has impaired their practical use.Despite considerable effort expended on improving DNA vaccine delivery,only minute amounts of Ag are available for immune induction following DNA vaccination.Two complementary strategies have been used to improve and modulate the immune response induced by DNA vaccines i)supplementing DNA vaccines with plasmids encoding cytokinesand(ii)targeting the Ag encoded by DNA vaccine through genetically fusing the Ag to molecules binding cell surface receptors. This paper reviews recent progress in these two areas and possible mechanisms responsible for the observed effects.?2001 Elsevier Science Ltd.All rights reserved. Keywords NA vaccination;Cytokine;Targeting;Chemokine;Costimulatory molecules |
金蟲 (小有名氣)
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DNA疫苗的遺傳佐劑 摘要 DNA疫苗表現(xiàn)在多數(shù)動物物種和人類上低效能的誘導免疫應答限制了它們的實際應用。盡管在提高DNA疫苗“誘導”上花費了相當努力,只有極少量的Ag在DNA疫苗的作用下發(fā)生免疫應答。過去有兩種方法來提高和調(diào)節(jié)DNA疫苗誘導的免疫應答:1)補充帶有細胞因子編碼質(zhì)粒的DNA疫苗2)通過DNA疫苗融合Ag到和細胞表面受體結(jié)合的分子來靶向編碼Ag。本文綜述了近年來在這兩個領域的進展和可能的機制,以及研究其效果。 關鍵詞 DNA疫苗 細胞因子 靶向 化學因子 共刺激分子 |
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