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yyn0452木蟲 (正式寫手)
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[交流]
求翻譯兩段話
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First, we computed a correlation matrix for each amino acid: All instances of codons for a given amino acid were extracted, and the identity of the next synonymous codon in the same reading frame was determined. Based on this, the frequency of each possible codon pair was established and compared to the frequency expected under the assumption of random distribution, given the observed codon frequencies (product of individual frequencies). The results were then expressed as number of standard deviations from the expected (Z transform) or percent deviation from the expected,respectively. The autocorrelation results in Table 1 and Table S2 were computed as follows. For each sequence and for each of the nine amino acids with isoaccepting tRNAs (Ala, Arg, Gly, Iso, Leu, Pro, Ser, Thr, and Val) the number of consecutive pairs of codons were counted. The expected number of consecutive pairs was computed as the products of the frequencies of the individual codons of each pair in the database. A Z-transform, subtracting the expected counts from the observed and dividing by the standard deviation (estimated assuming a binomial distribution) was performed and the results expressed as standard deviations from the expected value. The same results were expressed as percentages by subtracting the expected counts from the observed counts and dividing by the expected counts. |
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yyn0452(金幣+10): 2010-05-04 09:05
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首先，我們計(jì)算每一個(gè)相關(guān)的氨基酸矩陣：對于一個(gè)給定氨基酸，提取所有的密碼子的實(shí)例,以及確定同一配對位置的同義密碼子的身份。在此基礎(chǔ)上，對建立每個(gè)可能的密碼子配對頻率，由觀測到的密碼子頻率（各自頻率乘積），就能與隨機(jī)分布的假設(shè)預(yù)期頻率相比較。結(jié)果則表示成期望（Z變換）或偏離預(yù)期的百分比標(biāo)準(zhǔn)偏差數(shù) 表1和表S2的自相關(guān)結(jié)果，分別計(jì)算如下。對于每個(gè)序列和9個(gè)與isoaccepting個(gè)tRNA（丙氨酸，精氨酸，甘氨酸，異亮氨酸，脯氨酸，絲氨酸，蘇氨酸，和纈氨酸）的密碼子連續(xù)對數(shù)個(gè)氨基酸進(jìn)行計(jì)數(shù)。對預(yù)期的連續(xù)數(shù)計(jì)算，作為對數(shù)據(jù)庫中的每個(gè)個(gè)人密碼子配對的頻率的乘積。A Z變換，從觀測減去預(yù)期的數(shù)量和除以標(biāo)準(zhǔn)差估計(jì)假設(shè)一個(gè)二項(xiàng)分布（），同時(shí)從預(yù)期值標(biāo)準(zhǔn)差表示的結(jié)果。同樣的結(jié)果表示為百分比減去預(yù)計(jì)觀察計(jì)數(shù)計(jì)數(shù)和計(jì)數(shù)除以預(yù)期。 |
3樓2010-04-30 07:37:34
cszhangdy
木蟲 (著名寫手)
- 翻譯EPI: 1
- 應(yīng)助: 0 (幼兒園)
- 金幣: 1563.2
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- 注冊: 2010-01-04
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- 專業(yè): 計(jì)算機(jī)應(yīng)用技術(shù)
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sirljz(金幣+2):謝謝交流 2010-04-29 17:56
yyn0452(金幣+5, 翻譯EPI+1): 2010-05-04 09:05
sirljz(金幣+2):謝謝交流 2010-04-29 17:56
yyn0452(金幣+5, 翻譯EPI+1): 2010-05-04 09:05
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第一段： 首先，對于每一個(gè)氨基酸，我們計(jì)算一個(gè)相關(guān)矩陣：對于一個(gè)給定的氨基酸，提取其所有的遺傳密碼子，并且其在同一個(gè)（reading Frame）內(nèi)的同義密碼子的標(biāo)識也確定下來了。基于此，可以獲取每一個(gè)可能的密碼子對的頻率，同時(shí)，假如給定觀測到的密碼子的頻率（各自頻率的乘積，）就可以與假設(shè)在隨機(jī)分布的前提下的頻率的期望相比較。比較的結(jié)果可以各自的表示成期望+- 標(biāo)準(zhǔn)差，或者（標(biāo)準(zhǔn)差/期望）*100%。 [ Last edited by cszhangdy on 2010-4-29 at 17:02 ] |
2樓2010-04-29 16:56:35
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