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hihoney
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包含題目 【題目】A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol 【摘要】This study examines the current knowledge of physiological and clinical effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are explored, such as the capability of THC and CBD to act as anti-inflammatory substances independent of cyclo-oxygenase (COX) inhibition. CBD is demonstrated to antagonise some undesirable effects of THC including intoxication, sedation and tachycardia, while contributing analgesic, anti-emetic, and anti-carcinogenic properties in its own right. In modern clinical trials, this has permitted the administration of higher doses of THC, providing evidence for clinical efficacy and safety for cannabis based extracts in treatment of spasticity, central pain and lower urinary tract symptoms in multiple sclerosis, as well as sleep disturbances, peripheral neuropathic pain, brachial plexus avulsion symptoms, rheumatoid arthritis and intractable cancer pain. Prospects for future application of whole cannabis extracts in neuroprotection, drug dependency, and neoplastic disorders are further examined. The hypothesis that the combination of THC and CBD increases clinical efficacy while reducing adverse events is supported. [ Last edited by hihoney on 2010-5-7 at 17:49 ] |
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2樓2010-05-08 10:31:16
hihoney 
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sdywhxlql
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hihoney(金幣+17, 翻譯EPI+1):多謝相助，A tale of two cannabinoids 化用《雙城記》的題目是為了說(shuō)明大麻的兩種成分，聯(lián)合使用會(huì)增加藥效么。 我如果想說(shuō)明一種酶具有兩種功能，能不能使用a tale of two enzymes?望指教。 http://emuch.net/bbs/viewthread.php?tid=2029922 2010-05-10 22:02:15
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題目：大麻素類報(bào)告：四氫大麻酚和大麻二酚聯(lián)合治療原理 摘要：本研究探討四氫大麻酚（THC）和大麻二酚（CBD）的生理和臨床療效并介紹了他們?cè)谒幤分苿┥贤瑫r(shí)使用的原理。探索Cannabinoid 和 vanilloid 的受體作用和非受體作用的機(jī)制，例如THC和CBD作為抗炎底物不受環(huán)氧酶（COX）抑制劑的的抑制。CBD表現(xiàn)出對(duì)THC的一些副作用表現(xiàn)出拮抗，包括中毒，鎮(zhèn)靜，心動(dòng)過(guò)速，而對(duì)鎮(zhèn)痛，反催吐和抗癌表現(xiàn)協(xié)同作用。現(xiàn)代臨床試驗(yàn)提供了大麻提取物在多發(fā)性硬化癥中強(qiáng)直性痙攣和中樞性疼痛及泌尿道癥狀，睡眠障礙，周圍神經(jīng)性疼痛，臂叢癥狀，風(fēng)濕性關(guān)節(jié)炎，頑固性癌性疼痛臨床有效性和安全性證據(jù)，允許THC的高劑量用法。我們進(jìn)一步考察了大麻植物整株提取物在神經(jīng)保護(hù)，藥物依賴以及腫瘤性疾病方面的未來(lái)潛在應(yīng)用。我們證實(shí)了將THC 和CBD聯(lián)合使用在降低副作用的同時(shí)也增加了藥物的療效。 希望對(duì)樓主有用 |
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hihoney
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5樓2010-05-09 09:05:24
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6樓2010-05-11 10:54:06
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