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[交流]
幫忙翻一個摘要（生命科學）
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We report here the genome sequence of an ancient human. Obtained from,4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 203, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains.We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
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軍醫(yī)
金蟲 (初入文壇)
- 翻譯EPI: 2
- 應助: 0 (幼兒園)
- 金幣: 3218.3
- 帖子: 44
- 在線: 7.2小時
- 蟲號: 860099
- 注冊: 2009-09-29
- 性別: GG
- 專業(yè): 發(fā)育生物學
3樓2010-05-24 08:31:45
軍醫(yī)
金蟲 (初入文壇)
- 翻譯EPI: 2
- 應助: 0 (幼兒園)
- 金幣: 3218.3
- 帖子: 44
- 在線: 7.2小時
- 蟲號: 860099
- 注冊: 2009-09-29
- 性別: GG
- 專業(yè): 發(fā)育生物學
beidong6938(金幣+2, 翻譯EPI+1):不夠?qū)I(yè)。 2010-05-25 11:34:32
| 我們研究了古代人的基因組序列。從4000年前的凍土層得到的頭發(fā)分析發(fā)現(xiàn)，基因組來自首個格林蘭島定居的男性個體，每隔203測序，覆蓋了二倍體基因組的79%，這已經(jīng)接近了現(xiàn)代測序技術的最大限度。我們鑒定了353151個高通量的單核苷酸多態(tài)性。其中6.8%之前沒有報道。我們估計漏讀的不足0.8%。我們再用功能性單核苷酸多態(tài)性分析了這個個體的形態(tài)特征并與當代人的多態(tài)性比較發(fā)現(xiàn)，這個古代人與當代人的多態(tài)性數(shù)量相近。這位我們提供了5500年前西伯利亞向新大陸遷移的證據(jù)，與當今的因紐特人和本地印第安人的產(chǎn)生無關。 |
2樓2010-05-23 15:25:48
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