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結果 氟單獨染毒組大鼠氟斑牙癥狀明顯。與溶劑對照組相比,氟單獨染毒組大鼠肝臟中GSH-Px、SOD活力降低,MDA含量升高,差異均有統(tǒng)計學意義(P<0.05);高濃度硒單獨染毒組SOD活力降低,差異均有統(tǒng)計學意義(P<0.05)。與氟單獨染毒組相比,中、高濃度硒單獨染毒組和高濃度硒+氟聯合染毒組大鼠肝臟中GSH-Px活力上升,差異均有統(tǒng)計學意義(P<0.05或P<0.01);低、中濃度硒單獨染毒組SOD活力上升,差異均有統(tǒng)計學意義(P<0.05);中濃度硒單獨染毒組和高濃度硒+氟聯合染毒組MDA含量下降,差異均有統(tǒng)計學意義(P<0.05)。各染毒組大鼠肝臟中T-AOC活力間比較,差異無統(tǒng)計學意義。與溶劑對照組相比,氟單獨染毒組和低濃度硒+氟聯合染毒組大鼠肝組織中NF-κB表達水平升高,差異均有統(tǒng)計學意義(P<0.05)。與氟單獨染毒組相比,低濃度硒單獨染毒組大鼠肝組織中NF-κB表達水平降低,差異有統(tǒng)計學意義(P<0.05)。病理學結果顯示,氟+硒聯合染毒組大鼠肝細胞變性壞死程度明顯減輕,且肝細胞變性壞死程度隨著硒染毒濃度的升高而呈下降趨勢。 Results Fluoride single exposure group showed obvious symptoms of dental fluorosis. Compared with the control, the GSH-Px, SOD activity in rat liver from fluoride single exposure group decreased, and MDA content increased, the differences were statistically significant (P <0.05); the SOD activity of high concentrations of selenium single exposure group reduced, the differences were statistically significant (P <0.05). Compared with single exposure group, the GSH-Px activity of high concentrations of selenium single exposure group and the high concentration of selenium-fluoride combined exposure group in rat liver increased, the differences were statistically significant (P <0.05 or P <0.01); the SOD activity of low concentrations and middle concentrations of selenium in the single exposure group increased, the differences were statistically significant (P <0.05); the MDA content of middle concentration of selenium single exposure group and the high concentration of fluoride- selenium combined exposure group was decreased, the differences were statistically significant (P <0.05). The differences of T-AOC activity in Liver of rats among all exposure groups difference were not statistically significant. Compared with the control group, NF-κB expression level in rat liver from fluoride single exposure group and the low fluoride concentration combined with selenium exposure group, the differences were statistically significant (P <0.05). compared with Fluoride single exposure group, the NF-κB expression level in rat liver from low concentration of selenium single exposure group decreased significantly (P <0.05). Pathology results showed the rats from fluoride-selenium combined exposure ameliorate significantly the degeneration and necrosis of liver cells, and the extent of degeneration and necrosis of liver cells decreased with the rise of the concentration of selenium. |
禁蟲 (職業(yè)作家)
|
氟單獨染毒組大鼠氟斑牙癥狀明顯。與溶劑對照組相比,氟單獨染毒組大鼠肝臟中GSH-Px、SOD活力降低,MDA含量升高,差異均有統(tǒng)計學意義(P<0.05);高濃度硒單獨染毒組SOD活力降低,差異均有統(tǒng)計學意義(P<0.05)。 Most of the rats which received fluoride single exposure (Group x) showed obvious symptoms of dental fluorosis. Compared with the control group, the activities of GSH-Px, SOD in livers of the rats from the single exposure group decreased, while the MDA content increased. For the high concentration selenium single exposure group, the SOD activity is reduced. All of the measurements in the current study have a statistically significant value of less than 0.05 (or better). |
禁蟲 (職業(yè)作家)
木蟲 (正式寫手)
|
Results The group with fluoride single exposure showed obvious symptoms of dental fluorosis. Compared with the control, the GSH-Px, SOD activity in rat livers from the group with fluoride single exposure decreased, and MDA content increased (P <0.05). The SOD activity from the group with high concentration selenium single exposure reduced, with statistical significance (P <0.05). Compared with single exposure group, the GSH-Px activity in rat livers from the group with high concentration selenium single exposure and those with high concentration of combined selenium-fluoride exposure increased, the differences were also statistically significant (P <0.05 or P <0.01); the SOD activities from the groups with low and middle concentrations of selenium single exposure increased (P <0.05); the MDA contents from the group with middle concentration selenium single exposure and the group with high concentration of combined fluoride- selenium exposure were decreased (P <0.05). The differences of T-AOC activity in the livers of rats among all exposure groups were not statistically significant. Compared with the control group, the differences of NF-κB expression level in rat livers from the group with fluoride single exposure and those combined with low fluoride concentration selenium exposure were statistically significant (P <0.05). Compared with fluoride single exposure group, the NF-κB expression level in rat livers from the group with low concentration of selenium single exposure decreased significantly (P <0.05). Pathological results showed that the rats from combined fluoride-selenium exposure significantly ameliorated the degeneration and necrosis of liver cells, and the extent of these decreased with the rise of selenium concentration. 注:已經修改如上。至少語法和句子結構上的毛病改過來了。等待其他蟲子再挑毛病,謝謝! |
| The group with fluoride single exposure showed obvious symptoms of dental fluorosis. Compared with the control, the activity of GSH-Px, SOD in rat liver from the group with fluoride single exposure decreased, and the MDA content increased (P <0.05); the SOD activity from the group with high concentration selenium single exposure reduced, with statistical significance(P <0.05). Compared with fluoride single exposure group, the GSH-Px activity in rat livers from the groups with middle, high concentration selenium single exposure and those with high concentration of combined selenium-fluoride exposure increased, the differences were also statistically significant (P <0.05 or P <0.01); the SOD activity from the groups with low and middle concentrations of selenium single exposure increased (P <0.05); the MDA contents from the group with middle concentration selenium single exposure and the group with high concentration of combined fluoride-selenium exposure were decreased (P <0.05). The differences of T-AOC activity in the Livers of rats among all exposure groups were not statistically significant. Compared with the control, the difference of NF-κB expression level in rat livers from the group with fluoride single exposure and those with low selenium-fluoride exposure increased, the differences were statistically significant (P <0.05).Compared with fluoride single exposure group, the NF-κB expression level in rat livers from the group with low concentration of selenium single exposure decreased (P <0.05). Pathology results showed that the rats from combined fluoride-selenium exposure significantly ameliorate the degeneration and necrosis of liver cells, and the extent of these decreased with the rise of selenium concentration. |
木蟲 (正式寫手)
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