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請幫忙看看這個審稿意見是什么意思?基因治療方面的,謝謝 已有2人參與
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最近投了一篇關(guān)于基因治療方面的文章,下面是審稿人給出的意見,個人感覺挺抽象的,不知道大家有沒有什么好的建議?特別是該如何回答呢?謝謝。 Reviewer #1: The results of the authors demonstrated that rAAV2-mediated β-globin virus can efficiently mediate the expression of normal β-globin gene in fetal hematopoietic cells from β-thalassemia patients, for at least 21-35 days in the recipient mice and the level of human β-globin expression significantly increased by 1.2-1.8 folds, as compared with that of controls. So, for the final potential use of rAAV-based clinical gene therapy for human β-thalassemia, more experimental works should be done to answer the questions: ⑴Actually how are the durability and the stability of the rAAV-based transduction? ⑵How is the level of peripheral hemoglobin after the rAAV-based gene therapy? |
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