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[資源]
【資源】Cancer: Predictions in lymphoma
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The presence of a specific cell type in people with lymphoma is negatively associated with survival, providing a new biomarker with potential clinical applications (Proc. Natl. Acad. Sci. USA 107, 12747–12754). Jonathan Irish et al. used single-cell profiling in samples of human follicular lymphoma and found a subset of lymphoma cells with defective B cell antigen receptor (BCR) signaling. Jonathan Irish The more of these cells in each tumor, the shorter the overall subject survival. Moreover, these lymphoma cells increased in number as tumors relapsed after chemotherapy. Interestingly, BCR signaling could be reactivated in the defective cells, indicating that BCR signaling was not altogether absent but somehow suppressed. Mechanistically, tumors with high counts of defective BCR cells had less interleukin-7 signaling in infiltrating T cells, but additional work will be required to understand how these cells emerge and what their downstream effects are. In addition to representing a potential biomarker, the existence of cells with defective BCR signaling may provide new targets against follicular lymphoma.—JCL |
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