 |
 |
 |
| 24小時(shí)熱門(mén)版塊排行榜 |
- >論壇更新日志 (1337)
- >考研 (112)
- >導(dǎo)師招生 (90)
- >蟲(chóng)友互識(shí) (65)
- >基金申請(qǐng) (32)
- >休閑灌水 (18)
- >碩博家園 (13)
- >博后之家 (12)
- >教師之家 (10)
- >論文投稿 (9)
- >考博 (8)
- >微米和納米 (7)
- >找工作 (7)
- >經(jīng)濟(jì)學(xué) (6)
- >文獻(xiàn)求助 (6)
- >公派出國(guó) (6)
 |
 |
 |
||
 |
 |
 |
 |
 |
| 4 | 1/1 | 返回列表 |
| 查看: 1121 | 回復(fù): 3 | |||
[交流]
【Original】Severe Food Allergies Turned Off in Mice
|
Scientists have discovered a way to turn off the immune system's allergic reaction to certain food proteins in mice, a discovery that could have implications for the millions of people who suffer severe reactions to foods, such as peanuts and milk. (Credit: iStockphoto/Tomo Jesenicnik) The findings, published online in the journal Nature Medicine, provide hope that the body could be trained to tolerate food allergies that lead to roughly 300,000 emergency room visits and 100 to 200 deaths each year. The research team, led by Shau-Ku Huang, Ph.D., a professor of medicine, and Yufeng Zhou, M.D., Ph.D., a postdoctoral fellow in the Division of Allergy and Clinical Immunology at Johns Hopkins University School of Medicine, discovered that one kind of immune cell in the gastrointestinal tract called lamina propria dendritic cells (LPDC) -- considered the first line of defense for a body's immune system -- expresses a special receptor, SIGNR1, which appears on the cells' surface and binds to specific sugars. By targeting this receptor using sugar-modified protein, researchers were able to keep food proteins that would have induced a severe, even deadly, allergic reaction from causing any serious harm. "There is no cure for food allergies, and the primary treatment is avoidance of the offending protein," Zhou says. "This could teach our bodies to create a new immune response and we would no longer be allergic to the protein." The researchers hope to confirm whether this promising process in mice can also occur in people. Food allergies are triggered by the immune system and, in some people, can cause severe symptoms or even a life-threatening reaction known as anaphylaxis. In the United States, it is estimated that six to eight percent of children under the age of three and nearly four percent of adults have food allergies, and the prevalence is rising. Because of the extreme difficulty in avoiding all food allergen exposure and the lack of effective treatments, preventive and therapeutic strategies are urgently needed, Zhou says. In the laboratory, Zhou and his colleagues took a food protein that causes allergies in mice and modified it by adding special sugars. They hypothesized that, when ingested by the mice, the modified proteins would be able to bind to what are known as the SIGNR1 receptors on the immune system cells. Bound in this way, the immune system would learn to tolerate the modified food protein -- and the protein would no longer induce an allergic reaction, even when consumed in its unmodified form. Zhou fed his mice the modified protein once a day for three days. Five days later, he tested them by feeding them the protein in its unmodified form. Another group of mice was not fed the modified protein at all. The severity of the allergic response to the unmodified protein -- which in the control-group mice tended to be tremors, convulsions and/or death -- was significantly decreased in those mice that had been pre-fed the modified protein. Some still had minor reactions like itchiness or puffiness around the eyes and snout, but none had serious ones. These mice appeared to be desensitized to the food protein, even when it was fed to them in its unmodified form, says Zhou. In this model, SIGNR1 plays a key role in shutting off some responses in the immune cells, but whether this is the only function of this receptor is, at present, unknown. |
回復(fù)此樓» 猜你喜歡
求調(diào)劑院校信息
已經(jīng)有4人回復(fù)
-
085600材料與化工306
已經(jīng)有4人回復(fù)
-
286求調(diào)劑
已經(jīng)有10人回復(fù)
-
328求調(diào)劑，英語(yǔ)六級(jí)551，有科研經(jīng)歷
已經(jīng)有9人回復(fù)
-
一志愿北京化工大學(xué)070300 學(xué)碩336求調(diào)劑
已經(jīng)有4人回復(fù)
-
286分人工智能專(zhuān)業(yè)請(qǐng)求調(diào)劑愿意跨考！
已經(jīng)有8人回復(fù)
-
資源與環(huán)境 調(diào)劑申請(qǐng)(333分)
已經(jīng)有5人回復(fù)
-
280求調(diào)劑
已經(jīng)有12人回復(fù)
-
269專(zhuān)碩求調(diào)劑
已經(jīng)有5人回復(fù)
-
材料學(xué)碩301分求調(diào)劑
已經(jīng)有7人回復(fù)
xia_chong
金蟲(chóng) (文壇精英)
- ESEPI: 43
- 應(yīng)助: 0 (幼兒園)
- 貴賓: 1.591
- 金幣: 10270.8
- 散金: 2377
- 紅花: 34
- 沙發(fā): 160
- 帖子: 12455
- 在線: 1941.8小時(shí)
- 蟲(chóng)號(hào): 804303
- 注冊(cè): 2009-07-06
- 性別: GG
- 專(zhuān)業(yè): 粒子物理學(xué)和場(chǎng)論
- 管轄: English Cafe
2樓2010-10-03 07:47:27
nono2009
超級(jí)版主 (文學(xué)泰斗)
No gains, no pains.
-
專(zhuān)家經(jīng)驗(yàn): +21105 - ESEPI: 1
- 應(yīng)助: 28684 (院士)
- 貴賓: 513.911
- 金幣: 2555230
- 散金: 27828
- 紅花: 2148
- 沙發(fā): 66666
- 帖子: 1602255
- 在線: 65200.9小時(shí)
- 蟲(chóng)號(hào): 827383
- 注冊(cè): 2009-08-13
- 性別: GG
- 專(zhuān)業(yè): 工程熱物理與能源利用
- 管轄: 科研家籌備委員會(huì)
3樓2010-10-03 08:58:48
xuediandongxi
鐵桿木蟲(chóng) (著名寫(xiě)手)
- ESEPI: 13
- 應(yīng)助: 5 (幼兒園)
- 金幣: 5466.3
- 散金: 190
- 紅花: 8
- 沙發(fā): 30
- 帖子: 2362
- 在線: 619.2小時(shí)
- 蟲(chóng)號(hào): 365730
- 注冊(cè): 2007-05-09
- 性別: MM
- 專(zhuān)業(yè): 環(huán)境化工
|
It is not easy for me to understand this article. Understanding it needs fundamental medical knowledge. a report about a chemical which can improve the social skills of the shy. A brain chemical dubbed 'the hormone of love' could encourage wallflowers to become more outgoing at social gatherings, a study shows. Now researchers have found it improves the social skills of the shy - but has little effect on those who are naturally confident. The finding could have implications for those with severe social deficiencies, often apparent in conditions like autism. They conducted a test of 27 healthy adult men, giving them the hormone or a placebo via a nasal spray and then asking them to perform an 'emphatic accuracy task'. This involved watching others discussing emotional moments in their lives, then rating how they felt those people were feeling. The scientists, whose research is published in Psychological Science, also measured the participants' social competency, using a test known as AQ which is usually used in autistic patients. They found that oxytocin did improve empathatic accuracy - but only among those who were less socially proficient in the first place. The more socially comfortable participants performed well on the empathic accuracy task regardless of whether they were on oxytocin or placebo, but less socially proficient participants performed significantly better on oxytocin, with their empathetic accuracy performance identical to that of the socially proficient participants. Prof Jennifer Bartz, of the Mount Sinai School of Medicine, said: 'Oxytocin is widely believed to make all people more empathic and understanding of others. 'Our study contradicts that. Instead, oxytocin appears to be helpful only for those who are less socially proficient. 'Our data show that oxytocin selectively improves social cognition in people who are less socially proficient, but had little impact on more socially proficient individuals.'While more research is required, these results highlight the potential oxytocin holds for treating social deficits in people with disorders marked by deficits in social. [ Last edited by xuediandongxi on 2010-10-3 at 12:13 ] |
4樓2010-10-03 11:46:51
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 singer32 的主題更新
| 4 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 286分人工智能專(zhuān)業(yè)請(qǐng)求調(diào)劑愿意跨考！ +4 | lemonzzn 2026-03-17 | 8/400 |
|
|---|---|---|---|---|
|
|
[考研] 資源與環(huán)境 調(diào)劑申請(qǐng)(333分) +5 | holy J 2026-03-21 | 5/250 |
|
|
[考研] 280求調(diào)劑 +11 | 咕嚕曉曉 2026-03-18 | 12/600 |
|
|
|
[考研] 333求調(diào)劑 +5 | 87639 2026-03-21 | 7/350 |
|
|
|
[考研] 求調(diào)劑 +4 | 要好好無(wú)聊 2026-03-21 | 4/200 |
|
|
|
[考研] 材料 271求調(diào)劑 +5 | 展信悅_ 2026-03-21 | 5/250 |
|
|
|
[考研] 298求調(diào)劑 +4 | 上岸6666@ 2026-03-20 | 4/200 |
|
|
|
[考研] 26考研一志愿中國(guó)石油大學(xué)(華東)305分求調(diào)劑 +6 | 嘉年新程 2026-03-15 | 6/300 |
|
|
|
[考研] 0805材料320求調(diào)劑 +3 | 深海物語(yǔ) 2026-03-20 | 3/150 |
|
|
|
[考研] 材料學(xué)學(xué)碩080502 337求調(diào)劑-一志愿華中科技大學(xué) +4 | 順順順mr 2026-03-18 | 5/250 |
|
|
|
[考研] 機(jī)械專(zhuān)碩299求調(diào)劑至材料 +3 | kkcoco25 2026-03-16 | 4/200 |
|
|
|
[考研] 303求調(diào)劑 +5 | 睿08 2026-03-17 | 7/350 |
|
|
|
[考研] 22408 344分 求調(diào)劑 一志愿 華電計(jì)算機(jī)技術(shù) +4 | solanXXX 2026-03-20 | 4/200 |
|
|
|
[考研] 材料學(xué)求調(diào)劑 +4 | Stella_Yao 2026-03-20 | 4/200 |
|
|
|
[考研] 材料學(xué)碩318求調(diào)劑 +5 | February_Feb 2026-03-19 | 5/250 |
|
|
|
[考研] 344求調(diào)劑 +6 | knight344 2026-03-16 | 7/350 |
|
|
|
[考研] 312求調(diào)劑 +8 | 陌宸希 2026-03-16 | 9/450 |
|
|
|
[考研] 考研求調(diào)劑 +3 | 橘頌. 2026-03-17 | 4/200 |
|
|
|
[考研]
 11408 一志愿西電，277分求調(diào)劑
+3
|
zhouzhen654 2026-03-16 | 3/150 |
|
|
|
[考研] 東南大學(xué)364求調(diào)劑 +5 | JasonYuiui 2026-03-15 | 5/250 |
|