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【其他】中科院上海有機所曹春陽課題組招收聯(lián)合培養(yǎng)的學生 已有8人參與
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中科院上海有機所曹春陽課題組招收聯(lián)合培養(yǎng)的學生 要求:1.有生物或者化學背景 2.研一或者研二的學生 3.最好是男生(方便安排住宿) 聯(lián)系方式:wangckun@163.com |
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具體情況如下: 曹春陽,男,1970年8月 出生。中國科學院上海有機化學研究所“百人計劃”研究員,課題組負責人。 1998年8月-2001年7月: 中國科學院上海有機化學研究所有機化學博士。 2001年8月-2004年1月: 美國約翰霍普金斯大學醫(yī)學院藥理系博士后。 2004年2月-2005年11月:美國約翰霍普金斯大學醫(yī)學院藥理系研究助理,核磁共振瓦里安譜儀500M與600M (配有低溫探頭)技術管理員。 2005年12月-2006年8月:美國加州膜蛋白結構研究中心Salk生物學研究所結構生物學實驗室研究助理。 2006年9月-現(xiàn)在:中科院上海有機化學研究所“百人計劃”研究員,課題組負責人。 主要研究方向與研究方法 1) 利用核磁共振(NMR)技術研究若干生物大分子溶液三維結構、動力學與功能關系。 2) 利用NMR研究許多重要酶在核酸復制過程中識別、剪切與修復核酸損傷位點的機制,以及相關蛋白與核酸相互作用機制。 3) 利用化學結構修飾(有機合成)與酶學方法研究與疾病相關的酶與底物相互作用機制。 4) 利用定點突變技術研究重要氨基酸及有關氨基酸側鏈在酶生物催化過程中的作用。 5) 基于生物大分子溶液三維結構及相關酶生物催化機制, 利用有機合成方法進行抗腫瘤藥物分子、其它藥物分 子合理化設計。 已發(fā)文章: 1) The Catalytic Power of Uracil DNA Glycosylase in the Opening of Thymine Base Pairs Chunyang Cao, Y.L. Jiang, Daniel Krosky, James T. Stivers Journal of the American Chemical Society, 2006, 128 (40), 13034-13035. 2) Dynamic opening of normal thymidine bases during enzymatic search for damaged sites in DNA Chunyang Cao, James T. Stivers Nature Structural and Molecular Biology 2004, 11(12), 1230-1236 3) Recognition of an Unnatural Difluorophenyl Nucleotide by Uracil DNA Glycosylase Y.L. Jiang; L. McDowell; D. Studelska; Chunyang Cao ; J. Schaefer, and James T. Stivers. Biochemistry, 2004, 43(49), 15429-15438. 4) Solution Structure of BmKK4, the First Member of Subfamily a-KTx 17 of Scorpion Toxins. Naixia, Zhang; Xiang, Chen; Minghua, Li; Chunyang, Cao; Yuefeng, Wang; Gong, Wu; Guoyuan, Hu; Houming, Wu, Biochemistry, 2004, 43, 12469-12476. 5) The merits of bipattite transition-state mimics for inhibition of uracil DNA glycosylase Yulin Jiang, Chunyang Cao, James T. Stivers, Fenhong Song, and Yoshi Ichikawa Bioorganic Chemistry 2004, 32 ( 4), 244-262. 6) The solution structure of the oxidized bovine microsomal cytochrome b5 mutant V45H Qi Zhang, Chunyang Cao, Houming Wu, Zhiqiang Wang, Yunhua Wang, Zhongxian Huang Protein Science 2004, 13(8), 2161-2169. 7) A novel zinc snap motif conveys structural stability to 3-methyladenine DNA glycosylase I. Keehwan Kwon, Chunyang Cao, and James T. Stivers The Journal of Biological Chemistry 2003, 278(23), 19442-19446. 8) Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I Chunyang Cao, Keehwan Kwon, Yulin Jiang, Alexander Drohat, James T. Stivers The Journal of Biological Chemistry 2003, 278(48), 48012-48020. 9) The solution structure of the oxidized bovine microsomal cytochrome b5 mutant V61H; Chunyang Cao, Houming Wu, Linrong Xue, Yunhua Wang, Zhongxian Huang; Biochemical and Biophysical Research Communications, 2003, 307(3), 600-609. 10) Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog. Yaofeng Wang, Dou Hong; Chunyang Cao, Zhang Naixia Mao Jifang; Jinbiao Ma, Houming Wu, Biochemical and Biophysical Research Communications 2003, 306(2), 582-9 11) NMR study of the effect on cytochrome b5 heme caused by the mutation in the residue Val45; Chunyang Cao, Yaofeng Wang, Houming Wu, Zhiqiang Wang, Yunhua Wang, Zhongxian Huang Biochimie 2003, 85(10), 1007-1016. 12) A large-scale progress for high purity taxol from bark extract of Taxus Yunnanesis; Xue Jun, Chunyang Cao, Jianmin Chen, Haishan Bu, Houming Wu; Chinese Journal of Chemistry, 2001,19(1), 82-90. 13) NMR Preliminary Study on cytochrome b5 mutant V45H; Chunyang Cao, Houming Wu, Zhiqiang Wang, Yunhua Wang, Zhongxian, Acta Chim. Sinica , 2000, 59(4), 578-586. (in Chinese) 14) Three-dimensional structure of Bmp03 from Venom of scorpion Buthus Martensii karscah; Fahu He, Yiming Li, Gong Wu, Chunyang Cao, Houming Wu, Acta Chimica Sinica, 2000, 58(7), 850-855. (in Chinese) 15) Synthesis and biological activities of substituted pyrazolo [4,5-e][1,3]thiazine derivatives. Jin, Guiyu; Chunyang Cao; Li, Lintao; Ren, Jun; Zhao, Guofeng. Nongyaoxue Xuebao 1999, 1(1), 15-19. (in Chinese) 16) Synthesis and biological activity of 1-aryl-4-substituted- pyrazolylcarbonylthio semicarbazides and related heterocyclic compounds. Jin, Gui-Yu; Hou, Zhen; Zhao, Guo-Feng; Chunyang Cao; Li, Yu-Chang. Gaodeng Xuexiao Huaxue Xuebao 1997, 18(3), 409-412. (in Chinese) 會議論文或論文摘要 17) NMR study of the effect on cytochrome heme caused by the mutation in the residue Pro40; Chunyang Cao, HouMing Wu, Yibing Tang, Wenxia Tang; Zhiqiang Wang, Yunhua Wang, Zhongxian Huang Abstracted invited paper the Proceedings of the 11th National Magnetic Resonance Conference of the CPS (Chinese Physical Society), 2000. 18) Uracil DNA Glycosylase Destabilizes Normal DNA Base Pairs Chunyang Cao, James T Stivers Abstracts of Papers, accepted in 228th ACS National Meeting, Phiadelphia, PA, United States, August 22-26, 2004 本課題組配備600兆核磁,即將購買800兆核磁,科研條件比較好,硬件設備齊全 相關詳細的待遇和課題情況,請咨詢曹春陽老師ccao@mail.sioc.ac.cn 不過目前而言本課題組的聯(lián)合培養(yǎng)學生待遇至少是500塊錢/月,免費提供住宿。 關于本課題的詳細信息可以咨詢曹春陽老師,也可以咨詢我 我的聯(lián)系方式是wangckun@163.com QQ 是1032457491 |
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