 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 1 | 1/1 | 返回列表 |
| 查看: 145 | 回復(fù): 0 | |||
biomill8358無(wú)蟲(chóng) (小有名氣)
|
[交流]
【分享】在多種組織中，Prdm16通過(guò)部分調(diào)節(jié)氧化壓力來(lái)增加干細(xì)胞的持續(xù)性
|
|
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress 在多種組織中，Prdm16通過(guò)部分調(diào)節(jié)氧化壓力來(lái)增加干細(xì)胞的持續(xù)性 Sergei Chuikov1,2,3,5, Boaz P. Levi1,2,3,5, Michael L. Smith1,2,3 and Sean J. Morrison1,2,3,4 1Howard Hughes Medical Institute, 2Department of Internal Medicine, 3Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA. nature cell biology VOLUME 12 | NUMBER 10 | OCTOBER 2010 摘要：To better understand the mechanisms that regulate stem cell identity and function, we sought to identify genes that are preferentially expressed by stem cells and critical for their function in multiple tissues. Prdm16 is a transcription factor that regulates leukaemogenesis1, palatogenesis2 and brown-fat development3–5, but which was not known to be required for stem cell function. We demonstrate that Prdm16 is preferentially expressed by stem cells throughout the nervous and haematopoieticsystems and is required for their maintenance. In the haematopoieticand nervous systems, Prdm16 deficiency led to changes in the levels of reactive oxygen species (ROS), depletion of stem cells, increased cell death and altered cell-cycle distribution. In neural stem/progenitor cells, Prdm16 binds to the Hgfpromoter, and Hgfexpression declined in the absence of Prdm16. Addition of recombinant HGF to Prdm16-deficient neural stem cells in cell culture reduced the depletion of these cells and partially rescued the increase in ROS levels. Administration of the anti-oxidant, N-acetyl-cysteine, to Prdm16-deficient mice partially rescued defects in neural stem/progenitor cell function and neural development. Prdm16 therefore promotes stem cell maintenance in multiple tissues, partly by modulating oxidative stress. 1.為了理解調(diào)節(jié)干細(xì)胞功能的機(jī)制，作者尋找了很多基因，這些基因優(yōu)先在干細(xì)胞中表達(dá)并且對(duì)于它們?cè)诙喾N組織中的功能起著至關(guān)重要的作用。 2. Prdm16 是一種轉(zhuǎn)錄因子，它調(diào)節(jié)著腭的發(fā)生，棕色脂肪的發(fā)生，但是還不知道這些是干細(xì)胞行使功能所需要的。 3.在造血系統(tǒng)和神經(jīng)系統(tǒng)中，Prdm16的缺失會(huì)導(dǎo)致ROS水平的改變，干細(xì)胞的缺失，增加細(xì)胞死亡率和改變細(xì)胞周期的分布。 4.在神經(jīng)干細(xì)胞和祖細(xì)胞中，Prdm16 是和Hgf啟動(dòng)子相結(jié)合的，并且當(dāng)缺少Prdm16 時(shí)，Hgf的表達(dá)量降低。 5.在缺少Prdm16的神經(jīng)干細(xì)胞中加入重組的HGF會(huì)降低干細(xì)胞的死亡同時(shí)能部分恢復(fù)ROS水平的增加。 更多資料請(qǐng)查看www.bioknow.cn |
回復(fù)此樓» 猜你喜歡
306求0703調(diào)劑一志愿華中師范
已經(jīng)有9人回復(fù)
-
一志愿吉大化學(xué)322求調(diào)劑
已經(jīng)有6人回復(fù)
-
求調(diào)劑
已經(jīng)有5人回復(fù)
-
344求調(diào)劑
已經(jīng)有3人回復(fù)
-
一志愿哈工大，085400，320，求調(diào)劑
已經(jīng)有3人回復(fù)
-
【考研調(diào)劑】化學(xué)專業(yè) 281分，一志愿四川大學(xué)，誠(chéng)心求調(diào)劑
已經(jīng)有13人回復(fù)
-
307求調(diào)劑
已經(jīng)有3人回復(fù)
-
【雙一流院校新能源、環(huán)境材料，材料加工與模擬招收大量調(diào)劑】
已經(jīng)有6人回復(fù)
-
26申博自薦
已經(jīng)有3人回復(fù)
-
資源與環(huán)境 調(diào)劑申請(qǐng)(333分)
已經(jīng)有6人回復(fù)
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 biomill8358 的主題更新
| 1 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 一志愿哈工大，085400，320，求調(diào)劑 +3 | gdlf9999 2026-03-24 | 3/150 |
|
|---|---|---|---|---|
|
[考研] 335求調(diào)劑 +4 | yuyu宇 2026-03-23 | 5/250 |
|
|
|
[考研] 材料/農(nóng)業(yè)專業(yè)，07/08開(kāi)頭均可，過(guò)線就行 +3 | 呵唔哦豁 2026-03-23 | 4/200 |
|
|
|
[考研] 材料專碩英一數(shù)二306 +8 | z1z2z3879 2026-03-18 | 8/400 |
|
|
|
[考研] 333求調(diào)劑 +3 | ALULU4408 2026-03-23 | 3/150 |
|
|
|
[考研]
 材料與化工考研調(diào)劑
+4
|
孅華 2026-03-22 | 4/200 |
|
|
|
[考研] 石河子大學(xué)（211、雙一流）碩博研究生長(zhǎng)期招生公告 +3 | 李子目 2026-03-22 | 3/150 |
|
|
|
[考研] 287求調(diào)劑 +8 | 晨昏線與星海 2026-03-19 | 9/450 |
|
|
|
[考研] 319求調(diào)劑 +4 | 小力氣珂珂 2026-03-20 | 4/200 |
|
|
|
[考研] 生物學(xué)調(diào)劑 +5 | Surekei 2026-03-21 | 5/250 |
|
|
|
[考博] 招收博士1-2人 +3 | QGZDSYS 2026-03-18 | 4/200 |
|
|
|
[考研] 265求調(diào)劑 +12 | 梁梁校校 2026-03-19 | 14/700 |
|
|
|
[考研] 22 350 本科985求調(diào)劑，求老登收留 +3 | 李軼男003 2026-03-20 | 3/150 |
|
|
|
[考研] 二本跨考鄭大材料306英一數(shù)二 +3 | z1z2z3879 2026-03-17 | 3/150 |
|
|
|
[考研] 330求調(diào)劑 +4 | 小材化本科 2026-03-18 | 4/200 |
|
|
|
[考研] 一志愿 西北大學(xué) ，070300化學(xué)學(xué)碩，總分287，雙非一本，求調(diào)劑。 +4 | 晨昏線與星海 2026-03-19 | 4/200 |
|
|
|
[考研]
 295復(fù)試調(diào)劑
+8
|
簡(jiǎn)木ChuFront 2026-03-19 | 8/400 |
|
|
|
[考研] 0856調(diào)劑，是學(xué)校就去 +8 | sllhht 2026-03-19 | 9/450 |
|
|
|
[論文投稿]
申請(qǐng)回稿延期一個(gè)月，編輯同意了。但系統(tǒng)上的時(shí)間沒(méi)變，給編輯又寫(xiě)郵件了，沒(méi)回復(fù)
 10+3
|
wangf9518 2026-03-17 | 4/200 |
|
|
|
[考研] 0703化學(xué)調(diào)劑 +5 | pupcoco 2026-03-17 | 8/400 |
|