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Informative diagnostics for personalized medicine
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In addition to in vitro biomolecular diagnostics, advanced imaging technologies such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) are having an increasingly important role in managing the treatment of disease, and chemical biologists can make substantial advances in the development of informative diagnostic imaging probes19. Disease-relevant small-molecule metabolic probes, active site binders, engineered proteins and new imaging tags, such as magnetic and optically active nanoparticles, will continue to help physicians monitor the spread of disease. The development of informative diagnostic methodologies is crucial if the biomedical research community is to realize the full potential of molecularly targeted therapeutics. Although early successes from the modern drug discovery process have offered hope for the personalized treatment of disease, a grand challenge now lies in the development of individualized diagnostic tools—a challenge that must be met to translate this promise into the improved treatment of human disease. Chemical biologists are well positioned to lead this charge by expanding their efforts to include the development of informative clinical diagnostic methodologies, which should include collaborations with scientists with expertise in technologies that may just be appearing on the horizon. |
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| 除了體內(nèi)生物分子上的診斷,先進(jìn)的成像技術(shù)如正電子斷層掃描儀(PET)以及功能性核磁共振造影(fMRI)在治療疾病上日益重要,化學(xué)生物學(xué)家在影像診斷學(xué)的探索上也取得了大量的進(jìn)步。疾病相關(guān)的小分子代謝探針,活性部位粘合劑,工程蛋白以及新的成像標(biāo)記物比如具有磁性和光學(xué)活性的納米粒子將繼續(xù)幫助內(nèi)科醫(yī)生監(jiān)控疾病的蔓延,如果生物醫(yī)學(xué)研究社群要實(shí)現(xiàn)分子靶標(biāo)治療上的全部潛能,診斷方法學(xué)的發(fā)展是最關(guān)鍵的,盡管現(xiàn)代藥物發(fā)現(xiàn)過程的早期的成功已經(jīng)為疾病的個(gè)性化治療提供希望,巨大的挑戰(zhàn)在于發(fā)展發(fā)展個(gè)體化診斷工具,這個(gè)挑戰(zhàn)就是必須實(shí)現(xiàn)把這項(xiàng)期望轉(zhuǎn)變成治療人類疾病的改進(jìn)方法,化學(xué)生物學(xué)家恰好處于通過他們的努力來知道這項(xiàng)使命以推動(dòng)臨床診斷方法學(xué)的發(fā)展的位置上。這就包括與技術(shù)上有專門知識(shí)科學(xué)家的合作,該技術(shù)可能已經(jīng)初露端倪。 |
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