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Clinical Manifestations of Spinal DISH Clinical symptoms in spinal DISH are usually mild and include spinal stiffness and mild intermittent and nonradiating thoracolumbar pain that becomes evident in middle age. Generally, no significant change occurs in normal spinal mechanics, and the clinical findings are usually mild in comparison with the extent of the radiographic abnormalities. With progression of the disease, pain and stiffness may involve the lumbar and cervical segments [2]. Occasionally, patients with DISH may have severe limitation of spinal mobility and associated postural abnormality as is seen with advanced ankylosing spondylitis [7]. Prominent flowing ossifications of DISH in the cervical spine can cause dysphagia [2, 4, 8]. However, many patients with DISH are asymptomatic and their disease is discovered incidentally [4]. The association of ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum with DISH may explain, in part, the occasional presence of neurologic findings in patients with DISH [2, 9]. Sharma et al. [10] showed in retrospective analysis that 15% of patients with DISH presenting to a particular neurosurgical unit had serious neurologic manifestations requiring neurosurgical intervention. |
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脊椎DISH(彌漫性特發(fā)性骨質(zhì)增生癥)的臨床表現(xiàn) 脊椎DISH的臨床癥狀表現(xiàn)通常比較輕微,表現(xiàn)為脊椎僵硬,間歇性輕微胸腰部疼痛,步入中年后癥狀變明顯。通常情況下,正常的脊柱力學(xué)不會發(fā)生顯著變化,臨床表現(xiàn)與x光異常的程度相比也比較輕微。隨著疾病的惡化,疼痛和僵硬感會發(fā)展到腰椎、頸椎部位;偶爾情況下,DISH患者的脊椎活動嚴(yán)重受限,相關(guān)姿勢異常,類似于強直性脊柱炎。脊椎段的DISH導(dǎo)致的突出性流動骨化會引起吞咽困難。但許多患有DISH的病人沒有癥狀,病狀是附帶檢查出來的。DISH引起的尾椎后縱韌帶骨化合并黃韌帶骨化癥,或許可以解釋DISH病人的神經(jīng)功能方面癥狀的偶然存在性。Sharma等在回顧性分析中報道,接受神經(jīng)外科檢查的DISH病人中,有15%的病人患有嚴(yán)重的神經(jīng)系統(tǒng)病癥,需要神經(jīng)外科的介入。 |
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