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Especially because of markedly more distant leaving groups, long-range intra- and interstrand cross-links (CLs) are formed in DNA which affect DNA conformation, are recognized by specific proteins and repaired differently in comparison with the CLs of cisplatin and its mononuclear analogs |
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特別是因為明顯更遠的離去基團,DNA中形成了鏈內(nèi)配對及鏈間配對進而影響到了DNA的構(gòu)象,并被特殊蛋白所識別及修復,該識別與修復相比于順鉑及其單核類似物的配對是不同的。 Especially because of markedly more distant leaving groups, long-range intra- and interstrand cross-links (CLs) are formed in DNA which affect DNA conformation, are recognized by speci?c proteins and repaired differently in comparison with the CLs of cisplatin and its mononuclear analogs |
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