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【分享】在小鼠大腦中特異表達(dá)的長(zhǎng)非編碼RNA
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SPECIFIC EXPRESSION OF LONG NONCODINGRNAS IN THE MOUSE BRAIN 在小鼠大腦中特異表達(dá)的長(zhǎng)非編碼RNA PNAS January 15, 2008 摘要：A major proportion of the mammalian transcriptomecomprises long RNAs that have little or no protein-coding capacity (ncRNAs). Only a handful of such transcripts have been examined in detail, and it is unknown whether this class of transcript is generally functional or merely artifact. Using in situhybridization data from the Allen Brain Atlas, we identified 849 ncRNAs(of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomicalregions, cell types, or subcellularcompartments. Examination of their genomic context revealed that the ncRNAswere expressed from diverse places including intergenic, intronic, and imprinted loci and that many overlap with, or are transcribed antisense to, protein-coding genes of neurological importance. Comparisons between the expression profiles of ncRNAsand their associated protein-coding genes revealed complex relationships that, in combination with the specific expression profiles exhibited at both regional and subcellularlevels, are inconsistent with the notion that they are transcriptional noise or artifacts of chromatin remodeling. Our results show that the majority of ncRNAsare expressed in the brain and provide strong evidence that the majority of processed transcripts with no protein-coding capacity function intrinsically as RNAs. 哺乳動(dòng)物轉(zhuǎn)錄組中的一個(gè)主要部分包含長(zhǎng)非編碼RNA，它們沒(méi)有或很少有蛋白編碼能力。只有一部分被發(fā)現(xiàn)并進(jìn)行了深入的研究，大部分還未知。 艾倫腦圖譜利用原位雜交，在成年小鼠大腦中發(fā)現(xiàn)了849ncRNA的表達(dá)，并且絕大多數(shù)與特異的神經(jīng)解剖區(qū)域，細(xì)胞類(lèi)型或亞細(xì)胞定位相關(guān)。 比較ncRNA和與它們相關(guān)的蛋白編碼基因揭示了兩者間的復(fù)雜關(guān)系，與在區(qū)域和亞細(xì)胞水平的特異表達(dá)結(jié)合，說(shuō)明這些ncRNA并不是噪音或者染色質(zhì)重塑的加工品。 我們的結(jié)果表明ncRNA在大腦中的表達(dá)為不具蛋白編碼能力的轉(zhuǎn)錄物作為RNA產(chǎn)生功能提供了強(qiáng)有力的證據(jù)。 更多資料請(qǐng)登錄www.bioknow.cn |
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