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linyingjia至尊木蟲 (職業(yè)作家)
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[資源]
【分享】腫瘤學(xué)中又一篇經(jīng)典必讀文章 Hallmarks of Cancer: The Next Generation
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做腫瘤的一定都知道Robert A. Weinberg，他在2000年發(fā)表在Cell上的《The hallmarks of cancer》現(xiàn)在的引用次數(shù)已經(jīng)超過(guò)10000次，幾乎做腫瘤的每一個(gè)人都會(huì)看這么一篇經(jīng)典文章。在2011年3月4日，他又在Cell上繼續(xù)發(fā)表了題為《Hallmarks of Cancer: The Next Generation》的文章，將腫瘤的六種武器擴(kuò)充到十種武器。我覺得這又堪稱是腫瘤學(xué)研究中經(jīng)典與必讀文章了。 Summary The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. http://www.cell.com/abstract/S0092-8674(11)00127-9 [ Last edited by linyingjia on 2011-3-6 at 08:21 ] |
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