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| xcretion and that the patients have partially compensated for the hypoxia in another anner.In other cases of polycythemia an inappropriate increase in Ep production is present,since no physiologic hypoxic stimulus can be identified.The increased Ep in these patients appears to arise autonomously and is associated predom-inantly with renal lesions such as cysts,hydronephrosis,adenomas,and car-cinomas,but also with cerebellar hemangioblastomas,hepatomas,uterine leiomyomas,and a variety of tumors and hyperplasias of the endocrine organs.levels are depressed and phlebotomy induces only a modest increase in urinary Ep(102,103).The white cell and platelet counts are often increased,since the disease is not limited to abnormal red cell production.short-term cultures of marrow cells from patients with polycythemia vera indicated that the Ep-stimulated incrEp has been extracted from some of these tumors,and phlebotomy results in no further |
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+5/750
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+1/87
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至尊木蟲 (職業(yè)作家)
| In other cases of polycythemia an inappropriate increase in Ep production is present,since no physiologic hypoxic stimulus can be identified. 在其他紅細(xì)胞增多癥病例中,存在不適當(dāng)?shù)募t細(xì)胞生成素生成增加的情形,因?yàn)闆]有生理缺氧刺激可以與之相聯(lián)系。The increased Ep in these patients appears to arise autonomously and is associated predom-inantly with renal lesions such as cysts,hydronephrosis,adenomas,and car-cinomas,but also with cerebellar hemangioblastomas,hepatomas,uterine leiomyomas,and a variety of tumors and hyperplasias of the endocrine organs.在這些病人中增加的紅細(xì)胞生成素似乎是自發(fā)升高的,而且主導(dǎo)性地與腎損傷如囊腫、腎積水、腎上腺瘤、腫瘤相關(guān)聯(lián),而且還與小腦血管母細(xì)胞瘤、肝癌、子宮肌瘤以及多種腫瘤和內(nèi)分泌器官的增生相關(guān)。 |
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