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| The consequences are that the D-T interaction data currently available from public repositories are largely incomplete and the portion accessible is often nonhomogeneous and biased toward targets of common therapeutic interest. Therefore, conclusions derived from early topological analyses performed on D-T networks obtained from largely incomplete data should be taken with caution. |
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The consequences are that the D-T interaction data currently available from public repositories are largely incomplete and the portion accessible is often nonhomogeneous and biased toward targets of common therapeutic interest. Therefore, conclusions derived from early topological analyses performed on D-T networks obtained from largely incomplete data should be taken with caution. 由此導(dǎo)致的結(jié)果就是:現(xiàn)在可從公眾資源獲取的藥物-靶點相互作用數(shù)據(jù)大多數(shù)情況下并不完整,而且可獲得的資料不具有同質(zhì)性,更偏重于于常見治療藥物的靶點。因此基于大量不完整數(shù)據(jù)所進(jìn)行的早期藥物-靶點網(wǎng)絡(luò)拓?fù)浞治鏊贸龅慕Y(jié)論在采用時應(yīng)相當(dāng)謹(jǐn)慎。 |
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