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| 分析每天同一時間谷濃度考察穩(wěn)態(tài)情況,用最后一天完整給藥間隔的血藥濃度,分析Cmin(谷濃度)、Cmax(峰濃度)、Tmax(達峰時間),計算AUCss(穩(wěn)態(tài)AUC),AUMCss(穩(wěn)態(tài)AUMC),MRT和FI(波動系數(shù))等,其中Cmax、Cmin和Tmax用實測值,AUCss和AUMCss用梯形法計算。3 |
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| Analysis of trough concentrations at the same time each day were carried out to examine the steady state and plasma concentrations of the last day with the full dosing interval were adopted to determine Cmin (trough concentration), Cmax (peak concentration), Tmax (peak time) and calculate AUCss (steady-state AUC ), AUMCss (steady-state AUMC), MRT, and FI (fluctuation coefficient), etc., among them, the measured values of Cmax, Cmin, and Tmax were used directly, AUCss and AUMCss were calculated through trapezoidal method. |
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