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| 本帖產(chǎn)生 1 個 翻譯EPI ，點擊這里進行查看 | ||
polarmouse鐵蟲 (初入文壇)
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[求助]
求兩段翻譯，非常緊急，感激涕零
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In open-label, randomized, three-period, three-treatment crossover studies, 10 subjects received 10 mg A, 45 mg B or the combination, while20 subjects received 20 mg A, 1000 mg C or the combination. In an open-label, randomized, five-period, five-treatment, unbalanced crossover study, 12 subjects first received 20 mg A, 4 mg D or the combination, and afterward 100 mg sitagliptin or sitagliptin plus 20 mg A. Blood samples were taken over 72 h of each treatmentperiod. Lack of PK interaction was defined as the ratio of geometric means and 90% confidence interval (CI) for combination:monotherapy being within the range of 0.80–1.25 。 Co-administration of A withB, C or D had no effect on A maximum plasma concentration (Cmax) or area under the plasma concentration-time curve (AUC). Similarly, A did not affect the Cmax or AUC for the co-administered drug, except for slight extensions of the 90% CI for the ratio of geometric means for B AUC (upper limit 1.29) andC Cmax (lower limit 0.75). All monotherapies and combination therapies were well tolerated. A can be co-administered with B、C、Dwithout dose adjustment of either drug |
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polarmouse
鐵蟲 (初入文壇)
- 應助: 0 (幼兒園)
- 金幣: 25.8
- 帖子: 24
- 在線: 4.1小時
- 蟲號: 924818
- 注冊: 2009-12-10
- 專業(yè): 神經(jīng)系統(tǒng)和精神疾病其他科
2樓2011-05-08 11:43:15
polarmouse
鐵蟲 (初入文壇)
- 應助: 0 (幼兒園)
- 金幣: 25.8
- 帖子: 24
- 在線: 4.1小時
- 蟲號: 924818
- 注冊: 2009-12-10
- 專業(yè): 神經(jīng)系統(tǒng)和精神疾病其他科
3樓2011-05-08 11:43:29
polarmouse
鐵蟲 (初入文壇)
- 應助: 0 (幼兒園)
- 金幣: 25.8
- 帖子: 24
- 在線: 4.1小時
- 蟲號: 924818
- 注冊: 2009-12-10
- 專業(yè): 神經(jīng)系統(tǒng)和精神疾病其他科
4樓2011-05-08 11:43:49
Mally89
鐵桿木蟲 (職業(yè)作家)
T_T
- 翻譯EPI: 79
- 應助: 7 (幼兒園)
- 貴賓: 1.257
- 金幣: 5347.3
- 散金: 8936
- 紅花: 49
- 帖子: 3712
- 在線: 1225.5小時
- 蟲號: 1150928
- 注冊: 2010-11-19
- 性別: MM
- 專業(yè): 腫瘤免疫
【答案】應助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
sltmac(金幣+41, 翻譯EPI+1): 2011-05-16 07:52:15
sltmac: 繼續(xù)努力~~ 2011-05-16 07:52:30
sltmac(金幣+41, 翻譯EPI+1): 2011-05-16 07:52:15
sltmac: 繼續(xù)努力~~ 2011-05-16 07:52:30
|
In open-label, randomized, three-period, three-treatment crossover studies, 10 subjects received 10 mg A, 45 mg B or the combination, while20 subjects received 20 mg A, 1000 mg C or the combination. In an open-label, randomized, five-period, five-treatment, unbalanced crossover study, 12 subjects first received 20 mg A, 4 mg D or the combination, and afterward 100 mg sitagliptin or sitagliptin plus 20 mg A。 在進行持續(xù)三個周期，隨機開放標記的三個處理交叉治療研究當中，10個樣本中加入10mg的A，45mg的B或者二者的混合物，另外20個樣本中加入20mg的A、1000mg的C或者二者的混合物。在另一個隨機開放標記，維持5個周期的5個交叉不平衡處理研究當中，首先向12個樣本中加入20mg A，4mg D或者二者混合物，然后再加入100mg西他列汀或加有20mgA的西他列汀。 |
5樓2011-05-08 15:22:48
Mally89
鐵桿木蟲 (職業(yè)作家)
T_T
- 翻譯EPI: 79
- 應助: 7 (幼兒園)
- 貴賓: 1.257
- 金幣: 5347.3
- 散金: 8936
- 紅花: 49
- 帖子: 3712
- 在線: 1225.5小時
- 蟲號: 1150928
- 注冊: 2010-11-19
- 性別: MM
- 專業(yè): 腫瘤免疫
【答案】應助回帖
|
Blood samples were taken over 72 h of each treatment period. Lack of PK interaction was defined as the ratio of geometric means and 90% confidence interval (CI) for combination:monotherapy being within the range of 0.80–1.25 。 每個處理周期72小時之后將血液樣本取出。根據(jù)幾何方法和混合物90%置信區(qū)間（在0.8-1.25范圍內(nèi)的單一治療）的比值來判定交叉反應中是否缺乏PK。 |
6樓2011-05-08 16:09:08
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