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落迦銀蟲 (小有名氣)
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急�。。∏笾幚碚撐恼g 要求語句很通順
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Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence. Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on disease states, drug metabolism and toxicity. We investigated gene expression in the heart (the ventricle and atrium) along with the main tissues of drug absorption, metabolism and excretion, namely, the GI tract (ileum), liver and kidney (medulla and cortex) and performed in silico pathway analysis to elucidate key pathways possibly affected by gender dimorphic expression proles. Surprisingly, we show that the post-transcriptional regulator, EIF2S3, is consistently highlighted across all six tissues examined: the gene was nearly three times over-expressed in male dogs compared to females, in all the tissues studied. This nding should be contrasted with the observation that the vast majority of genes showed no difference and for those where differences were found it was limited to one or two tissues. Thus, the discovery that EIF2S3 showed such large differences (common to all the tissues studied), was an intriguing nding. Pathway analysis showed tissue- specic gender dimorphic proles are apparent between male and female canines; interestingly, EIF2S3 appeared to play a key role in these pathways. High homology with the human EIF2S3 raises the prospect of an analogous role for sex-differences in humans. [ Last edited by 落迦 on 2011-5-30 at 22:11 ] |
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8814402
至尊木蟲 (職業(yè)作家)
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【答案】應(yīng)助回帖
★ ★
Mally89(金幣+2): 感謝應(yīng)助！~ 2011-05-31 10:56:19
落迦(金幣+20): OK了 非常感謝 2011-05-31 20:03:20
Mally89(金幣+2): 感謝應(yīng)助！~ 2011-05-31 10:56:19
落迦(金幣+20): OK了 非常感謝 2011-05-31 20:03:20
| Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. 家犬是臨床前藥物研發(fā)包括毒性評價中常用的主要實驗動物。As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence. 由于在臨床中出現(xiàn)性別不同毒性相左的資料，與藥物毒性相關(guān)的性別差異問題越來越顯現(xiàn)出其重要性。Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. 由于性別差異可能與更復(fù)雜的激素和/或潛在的基因表達差異，許多新出現(xiàn)的資料并不能簡單地通過體重或體內(nèi)脂肪的差異來解釋。The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. 家犬也在藥物毒性方面表現(xiàn)出性別差異。We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on disease states, drug metabolism and toxicity. 我們試圖闡明是否確實存在關(guān)鍵基因表達差異，如果存在差異，這些差異是否潛在地對疾病狀態(tài)、藥物代謝和毒性產(chǎn)生影響。We investigated gene expression in the heart (the ventricle and atrium) along with the main tissues of drug absorption, metabolism and excretion, namely, the GI tract (ileum), liver and kidney (medulla and cortex) and performed in silico pathway analysis to elucidate key pathways possibly affected by gender dimorphic expression proles.我們研究了心臟（心室和心房）以及藥物吸收、代謝和排泄有關(guān)的主要器官組織如消化道（回腸）、肝和腎（髓質(zhì)和皮質(zhì)）的基因表達，通過計算機通路分析來闡明可能被性別二態(tài)性表達所影響的關(guān)鍵通路。 |
2樓2011-05-31 09:02:16
8814402
至尊木蟲 (職業(yè)作家)
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★ ★
Mally89(金幣+2): 同上！~O(∩_∩)O~ 2011-05-31 10:56:52
落迦(金幣+10, 翻譯EPI+1): 謝謝了 2011-05-31 20:02:48
Mally89(金幣+2): 同上！~O(∩_∩)O~ 2011-05-31 10:56:52
落迦(金幣+10, 翻譯EPI+1): 謝謝了 2011-05-31 20:02:48
| Surprisingly, we show that the post-transcriptional regulator, EIF2S3, is consistently highlighted across all six tissues examined: the gene was nearly three times over-expressed in male dogs compared to females, in all the tissues studied.轉(zhuǎn)錄后調(diào)控子EIF2S3令人驚訝地在所有試驗的六種組織中均很突出：其基因在雄性犬中表達幾乎是雌性犬的3倍之多。 This nding should be contrasted with the observation that the vast majority of genes showed no difference and for those where differences were found it was limited to one or two tissues. 這種情形與絕大多數(shù)基因在不同性別不表現(xiàn)出差異或既就是有差異也局限于一或兩種組織中的的情形形成鮮明對照。Thus, the discovery that EIF2S3 showed such large differences (common to all the tissues studied), was an intriguing nding. 因此，EIF2S3表達的巨大差異是一個有趣的現(xiàn)象。Pathway analysis showed tissue- specic gender dimorphic proles are apparent between male and female canines; interestingly, EIF2S3 appeared to play a key role in these pathways. 通路分析顯示在雄性和雌性犬之間的組織特異性性別二態(tài)性proles是顯著的；非常有趣的是EIF2S3似乎在這些通路中發(fā)揮著重要作用。High homology with the human EIF2S3 raises the prospect of an analogous role for sex-differences in humans.犬與人EIF2S3基因具有高度同源性，這使得這一基因在人類（藥物毒性）性別差異研究方面顯示很好的前景。 |
3樓2011-05-31 09:28:36
zhaochenchuo
金蟲 (小有名氣)
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★ ★ ★
Mally89(金幣+3): 感謝應(yīng)助并鼓勵新蟲！~歡迎常來！~ 2011-05-31 10:57:16
落迦(金幣+20): 謝謝了 2011-05-31 20:03:00
Mally89(金幣+3): 感謝應(yīng)助并鼓勵新蟲！~歡迎常來！~ 2011-05-31 10:57:16
落迦(金幣+20): 謝謝了 2011-05-31 20:03:00
| Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. 家犬是臨床前藥物研究（包括毒性評估）所用主要動物物種。As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence.根據(jù)臨床研究中兩性別毒性數(shù)據(jù)，與藥物相關(guān)的性別毒性差異將顯著增加。 Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. 這些臨床數(shù)據(jù)中大部分不能簡單地用體重或機體脂肪差異來解釋，由于基因表達的不同，性別差異可能與更復(fù)雜的激素和/或蛋白質(zhì)相關(guān)。The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. 藥物所致毒性研究中，犬類也表現(xiàn)出了一些性別差異，所以當(dāng)前研究中我們研究了雌雄兩性犬與毒性相關(guān)組織中基因表達水平的差異。We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on disease states, drug metabolism and toxicity.我們想要解釋主要基因表達是否存在差異，如果存在，這些性別差異是否可能影響疾病狀態(tài)、藥物代謝和毒性。 We investigated gene expression in the heart (the ventricle and atrium) along with the main tissues of drug absorption, metabolism and excretion, namely, the GI tract (ileum), liver and kidney (medulla and cortex) and performed in silico pathway analysis to elucidate key pathways possibly affected by gender dimorphic expression proles.我們通過計算機分析研究了心臟（心房、心室）和藥物吸收、代謝和消除主要組織即消化道（回腸）、肝臟和腎臟（髓質(zhì)和皮質(zhì)）中基因表達情況，來解釋關(guān)鍵通路可能受性別差異表達特征的影響。 |
4樓2011-05-31 10:47:29
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