[交流] 西替利嗪在兒童用藥的主要風(fēng)險是什么？

西替利嗪用于兒童，不同資料說法不一：包括“不推薦用于6歲以下兒童”，“不推薦用于12歲以下兒童”，“2歲以下兒童禁用”，“可用于兒童及妊娠或哺乳的婦女”不一而足。

目前權(quán)威的說法是？

西替利嗪在兒童用藥的主要風(fēng)險是什么？

希望有最新資料的站友給予解釋

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1樓 2011-07-13 11:07:14

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章輔

木蟲 (初入文壇)

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★ ★ ★
8814402(金幣+1):謝謝參與
中藥2000(金幣+2): 謝謝。 2011-07-13 17:01:31

四版臨床藥理學(xué)說的很清楚用于兒童時使用左旋西替利嗪

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2樓2011-07-13 14:49:57

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8814402

至尊木蟲 (職業(yè)作家)

謝謝，但請回答我的兩個問題好嗎？

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3樓2011-07-13 21:28:14

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8814402

至尊木蟲 (職業(yè)作家)

★
qinhy(金幣+1): 謝謝回帖交流~ 2011-07-14 17:55:39

以下是國外網(wǎng)站的資料，顯示對6個月以上兒童進(jìn)行過安全性評價，應(yīng)該可以使用。
國外上市的有片劑、糖漿劑和咀嚼片。
ZYRTEC (cetirizine) can be taken without regard to food consumption. ZYRTEC (cetirizine) is available
as 5 mg and 10 mg tablets, 1 mg/mL syrup, and 5 mg and 10 mg chewable tablets
which can be taken with or without water.

Adults and Children 12 Years and Older: The recommended initial dose
of ZYRTEC (cetirizine) is 5 mg or 10 mg per day in adults and children 12 years and older,
depending on symptom severity. Most patients in clinical trials started at 10
mg. ZYRTEC (cetirizine) is given as a single daily dose. The time of administration may be
varied to suit individual patient needs.

Children 6 to 11 Years: The recommended initial dose of ZYRTEC (cetirizine) in children
aged 6 to 11 years is 5 mg or 10 mg once daily depending on symptom severity.
The time of administration may be varied to suit individual patient needs.

Children 2 to 5 Years: The recommended initial dose of ZYRTEC (cetirizine) in children
aged 2 to 5 years is 2.5 mg (? teaspoon) syrup once daily. The dosage in this
age group can be increased to a maximum dose of 5 mg per day given as 1 teaspoon
syrup once a day or one ? teaspoon syrup given every 12 hours, or one 5 mg chewable
tablet once a day.

Children 6 months to <2 years: The recommended dose of ZYRTEC (cetirizine) syrup
in children 6 months to 23 months of age is 2.5 mg (? teaspoon) once daily.
The dose in children 12 to 23 months of age can be increased to a maximum dose
of 5 mg per day, given as ? teaspoon (2.5 mg) every 12 hours. Syrup is recommended
for children under the age of 2 years.

Pediatric Use: The safety of ZYRTEC (cetirizine) has been demonstrated in pediatric
patients aged 6 months to 11 years. The safety of ZYRTEC (cetirizine) , at daily doses of
5 or 10 mg, has been demonstrated in 376 pediatric patients aged 6 to 11 years
in placebo-controlled trials lasting up to four weeks and in 254 patients in
a non-placebo-controlled 12-week trial. The safety of cetirizine has been demonstrated
in 168 patients aged 2 to 5 years in placebo-controlled trials of up to 4 weeks
duration. On a mg/kg basis, most of the 168 patients received between 0.2 and
0.4 mg/kg of cetirizine HCl. The safety of cetirizine in 399 patients aged 12
to 24 months has been demonstrated in a placebo-controlled 18-month trial, in
which the average dose was 0.25 mg/kg bid, corresponding to a range of 4 to
11 mg/day. The safety of ZYRTEC (cetirizine) syrup has been demonstrated in 42 patients aged
6 to 11 months in a placebo-controlled 7-day trial. The prescribed dose was
0.25 mg/kg bid, which corresponded to a mean of 4.5 mg/day, with a range of
3.4 to 6.2 mg/day.

The effectiveness of ZYRTEC (cetirizine) for the treatment of allergic rhinitis and chronic
idiopathic urticaria in pediatric patients aged 6 months to 11 years is based
on an extrapolation of the demonstrated efficacy of ZYRTEC (cetirizine) in adults with these
conditions and the likelihood that the disease course, pathophysiology and the
drug's effect are substantially similar between these two populations. Efficacy
is extrapolated down to 6 months of age for perennial allergic rhinitis and
down to 2 years of age for seasonal allergic rhinitis because these diseases
are thought to occur down to these ages in children. The recommended doses for
the pediatric population are based on cross-study comparisons of the pharmacokinetics
and pharmacodynamics of cetirizine in adult and pediatric subjects and on the
safety profile of cetirizine in both adult and pediatric patients at doses equal
to or higher than the recommended doses. The cetirizine AUC and Cmax in pediatric
subjects aged 6 to 23 months who received a mean of 2.3 mg in a single dose,
and in subjects aged 2 to 5 years who received a single dose of 5 mg of cetirizine
syrup and in pediatric subjects aged 6 to 11 years who received a single dose
of 10 mg of cetirizine syrup were estimated to be intermediate between that
observed in adults who received a single dose of 10 mg of cetirizine tablets
and those who received a single dose of 20 mg of cetirizine tablets.

The safety and effectiveness of cetirizine in pediatric patients under the age of 6 months have not been established.
Last reviewed on RxList: 5/17/2007
This monograph has been modified to include the generic and brand name in many instances.

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4樓2011-07-14 10:35:31

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