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煙云聽雨

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[求助] 求翻譯一段英文文獻(xiàn)(有機(jī)化學(xué))

This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). The scaffold readily participated in reductive amination with a diverse
range of aldehydes to provide a collection of tertiary amines in this series. Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these.

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念念不忘，必有回響

1樓 2011-07-17 08:22:29

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煙云聽雨(金幣+10, 翻譯EPI+1): 非常感謝 2011-07-21 09:00:56
Mally89(金幣+1): 感謝應(yīng)助！~ 2011-07-23 22:02:02

This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). 這一觀察使得我們可以研究提供三環(huán)骨架9的可選Diels–Alder/aza–Wittig 反應(yīng)序列，三環(huán)骨架9中含有未加修飾、易于按需進(jìn)行烷基化或酰胺化的堿性氮。The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. 支架使得多種多樣的醛類易于發(fā)生還原氨化反應(yīng)而得到一系列的叔胺。Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. 基于先前研究的堿性含氮化合物各異的GPCR親和性先例，我們推理此系列化合物應(yīng)該具有不錯的篩選結(jié)果。We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. 我們傾向于針對阿片受體和與鎮(zhèn)咳活性相關(guān)的Sig-R進(jìn)行篩選，我們已經(jīng)開始有關(guān)的橫斷面研究。

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2樓2011-07-20 12:07:45