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liugy2009金蟲 (小有名氣)
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[求助]
求翻譯文獻(xiàn)一段（有機(jī)化學(xué)）
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Summary and Final Comments. In this study, we have identified three sets of biaoctive compounds based on the tricyclic core of the Stemona alkaloid skeleton shown in Fig. 6. These compounds vary in their degrees of added structural complexity from a simple amide reduction (6{10}) to a greater than twofold increase of the molecular weight via an isocyanide MCR (14{26}). Each of these compounds has provided potent binding compounds that may be viewed as lead structures for further development. Moreover, we identified a particular chemical feature consistent with activity (a basic nitrogen atom), which suggested a scaffold-hopping maneuver that resulted in unique compounds with exquisite potency and selectivity against the Sig-Rs. |
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8814402
至尊木蟲 (職業(yè)作家)
- 翻譯EPI: 509
- 應(yīng)助: 18 (小學(xué)生)
- 貴賓: 0.381
- 金幣: 12916.1
- 散金: 47
- 紅花: 16
- 帖子: 4183
- 在線: 357.8小時(shí)
- 蟲號(hào): 1184404
- 注冊(cè): 2011-01-06
- 專業(yè): 藥物學(xué)其他科學(xué)問題
2樓2011-07-20 10:07:44
8814402
至尊木蟲 (職業(yè)作家)
- 翻譯EPI: 509
- 應(yīng)助: 18 (小學(xué)生)
- 貴賓: 0.381
- 金幣: 12916.1
- 散金: 47
- 紅花: 16
- 帖子: 4183
- 在線: 357.8小時(shí)
- 蟲號(hào): 1184404
- 注冊(cè): 2011-01-06
- 專業(yè): 藥物學(xué)其他科學(xué)問題
【答案】應(yīng)助回帖
★
liugy2009(金幣+40, 翻譯EPI+1): O(∩_∩)O~~~謝謝幫忙 2011-07-20 19:19:34
Mally89(金幣+1): 感謝應(yīng)助！~ 2011-07-23 22:02:26
liugy2009(金幣+40, 翻譯EPI+1): O(∩_∩)O~~~謝謝幫忙 2011-07-20 19:19:34
Mally89(金幣+1): 感謝應(yīng)助！~ 2011-07-23 22:02:26
| Summary and Final Comments.總結(jié)和最后評(píng)論 In this study, we have identified three sets of biaoctive compounds based on the tricyclic core of the Stemona alkaloid skeleton shown in Fig. 6. 本研究中，我們鑒定了基于斯替寧堿骨架三環(huán)核心的三個(gè)系列的活性化合物，見圖6.These compounds vary in their degrees of added structural complexity from a simple amide reduction (6{10}) to a greater than twofold increase of the molecular weight via an isocyanide MCR (14{26}).這些化合物在增加的結(jié)構(gòu)復(fù)雜性上各不相同。 Each of these compounds has provided potent binding compounds that may be viewed as lead structures for further development. 每種系列化合物都可選出可視作進(jìn)一步開發(fā)的先導(dǎo)化合物的高親和性化合物。Moreover, we identified a particular chemical feature consistent with activity (a basic nitrogen atom), which suggested a scaffold-hopping maneuver that resulted in unique compounds with exquisite potency and selectivity against the Sig-Rs.而且，我們還鑒定了與活性一致的一種特殊的化學(xué)特征---堿性氮原子，這提示支架變換策略可得到對(duì)Sig-R具有強(qiáng)烈活性和靈敏選擇性的獨(dú)特化合物。 |
3樓2011-07-20 11:24:06
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