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shekai新蟲(chóng) (初入文壇)
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[求助]
關(guān)于HSV-2生殖器皰疹病毒的研究進(jìn)展與攻克期待。 已有2人參與
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有數(shù)據(jù)顯示美國(guó)人有近6000萬(wàn)（近人口總數(shù)20%）感染了HSV-2生殖器皰疹病毒，該病很容易復(fù)發(fā)，是性傳播疾病一種，而且，聽(tīng)說(shuō)HSV-2和HSV-1兩種病毒比艾滋和肝炎病毒等都要簡(jiǎn)單點(diǎn)，HSV-2在人體不能得到根本清除是由于部分影藏在神經(jīng)細(xì)胞中，而類似于阿昔洛韋這類藥物不能進(jìn)入這類細(xì)胞，只能在發(fā)病時(shí)候，進(jìn)行治療。 這是一個(gè)很大的市場(chǎng)，聽(tīng)說(shuō)美國(guó)在研究根治的方面投入較大。 我本人是學(xué)工科的，但知道今后幾十年，在基因和納米領(lǐng)域，科技很可能會(huì)有突破技術(shù)發(fā)生。 我想請(qǐng)問(wèn)各位研究病毒學(xué)的同學(xué)，就您們的了解，人類攻破該類病毒，得到徹底治愈的藥物還會(huì)要多長(zhǎng)時(shí)間列？ 非常謝謝！期待您們的回復(fù)。 [ Last edited by silicare on 2014-2-18 at 09:00 ] |
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shekai
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2樓2011-08-26 20:10:35
qlxbya
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3樓2011-08-27 08:36:11
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4樓2011-08-27 16:28:16
| 頂一下。 |
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6樓2011-08-28 15:53:19
kevintz
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【答案】應(yīng)助回帖
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皰疹病毒很多種類，HSV-1,-2, VSV等等，人類很小時(shí)候就會(huì)感染一種或幾種，之后病毒潛伏在神經(jīng)細(xì)胞中，在身體抵抗力下降時(shí)，重新復(fù)發(fā)。 潛伏在神經(jīng)細(xì)胞中的病毒基因不表達(dá)或不完全表達(dá)，人體免疫系統(tǒng)和藥物都不能將其殺滅。研究策略現(xiàn)在一般有如下思路：1）誘導(dǎo)潛伏的病毒復(fù)發(fā)，后藥物治療；2）阻斷病毒潛伏相關(guān)的基因或蛋白。有些研究進(jìn)展，但20-30年內(nèi)很難有效根除。 |
7樓2011-08-28 20:47:56
qlxbya
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8樓2011-08-28 21:43:35
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9樓2011-08-30 19:28:09
qlxbya
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轉(zhuǎn)個(gè)我看到的國(guó)外消息： “Earlier this year I discussed Vical (VICL), one of those biotechnology companies that appear to be flying under almost everyone's radar. The corporation, based in San Diego, CA, has, for a young biotech company, a deep pipeline as well as two products on the market, one to protect farm-raised salmon and another to increase the survival time of dogs with oral melanoma. But what really excites me about Vical, in addition to its work on cancer immunotherapies and, specifically, its Phase III study of Allovectin®, is the company’s seminal research and development in the area of the herpes simplex virus and the development of the corporation’s herpes simplex virus type 2 or HSV-2 vaccine. 在美guo加州的這家公司就是 vical 它是一家主要致力研究治療生殖器皰疹的生化公司。（ 迷糊以前提及過(guò)這個(gè)藥而且多次提及。 ）這家公司目前主要專攻癌癥的免疫力治療還有就是已經(jīng)進(jìn)入三期實(shí)驗(yàn)的專制生殖器皰疹的藥名叫 allovectin 目前此藥已經(jīng)申請(qǐng)專利并注冊(cè)。 這是一個(gè)疫苗藥物。 Of the two serotypes identified, HSV-1 and HSV-2, the latter is most common in the United States. HSV-2 is a sexually transmitted virus which is the leading cause of genital herpes. Approximately one out of every six individuals in the United States and an estimated one out of every four worldwide is infected by HSV-2 before age 50. Even more disconcerting, perhaps, as noted by Vical at the recent BIO International Convention, 二型皰疹是性病在美guo很普遍。 每六個(gè)人中就有一個(gè)人有這個(gè)病， 世界范圍內(nèi)五十歲之前的人每四個(gè)人就有一個(gè)人有此病。 在今年召開(kāi)的那次生化會(huì)議上 這家公司把這些都做了論述 “[I]n the United States, at least 40 million people are infected with HSV-2, and approximately 1.6 million people are newly infected each year, with approximately 500,000 of those suffering from disease symptoms. Even higher infection rates are evident in developing countries, with further complications in people also infected with HIV.” 在美guo四千萬(wàn)人患有此病。 每一年新病人160萬(wàn)人。 其中這些病人中50萬(wàn)人是有疾病癥狀的。 （這說(shuō)明大多數(shù)人得病沒(méi)有癥狀， 而我們這些倒霉蛋都是有癥狀的） 發(fā)展中g(shù)uo家呈現(xiàn)上升趨勢(shì)， 艾滋患者的癥狀更復(fù)雜 Importantly, there is, currently, no cure for genital herpes. It is a recurrent, lifelong viral infection. But under a grant from the National Institute of Allergy and Infectious Diseases Division of the National Institutes of Health ((NIH)), the effort mounted by Vical is directed at developing a plasmid DNA-based vaccine to inhibit recurring lesions in patients latently infected with HSV-2. And while still in the preclinical stage, results have shown a reproducible statistically significant reduction in viral lesion occurrence in guinea pigs latently infected with HSV-2. 此病無(wú)法治愈。 是終生的病毒感染 （真難過(guò)） 但是在guo家健康部門的授權(quán)下， 這家公司正致力研究對(duì)付二型皰疹的基因基礎(chǔ)的疫苗來(lái)對(duì)付皰疹的復(fù)發(fā)。 雖然還沒(méi)有人體試驗(yàn)， 但是在豬身上的試驗(yàn)已經(jīng)成功， 能夠抑制復(fù)發(fā) Development of the HSV-2 vaccine is being done in collaboration with the University Of Washington School Of Medicine and the Sealy Center for Vaccine Development at the University of Texas Medical Branch under the NIH grant cited above. The initial focus will be for people already infected with HSV-2, with the goal of reducing or eliminating periodic viral flare-ups as well as viral shedding and transmission. 這項(xiàng)試驗(yàn)是與華盛頓大學(xué)和德克薩斯大學(xué)一起聯(lián)合進(jìn)行的。 是針對(duì)已經(jīng)感染生殖器皰疹病人的。 抑制復(fù)發(fā)， 防治傳染已經(jīng)減輕癥狀。 還有消滅病毒的活躍 What had researchers and medical practitioners excited at this year’s BIO International Convention were data presented by Vical that showed its therapeutic vaccine “…significantly reduced the recurrence of HSV-2 lesions in guinea pigs with latent infection (p<0.05).” Vical also presented data for a related prophylactic vaccine that demonstrated how this version “…protected mice against lethal HSV-2 challenge (p<0.0001), provided sterilizing immunity(p<0.05) and inhibited post-challenge viral shedding at the primary infection site (p<0.05) and viral load at the latent infection site (p=0.007).” 在今年的世界生化大會(huì)上， 這家公司公布了在豬身上實(shí)驗(yàn)的所有數(shù)據(jù)。 以及在耗子身上的試驗(yàn)結(jié)果。 數(shù)據(jù)顯示徹底被抑制。 What some consider even more exciting were the results announced a month later at the DNA Vaccines 2011 Conference. According to Sean M. Sullivan, Ph.D., Vical's Executive Director of Pharmaceutical Sciences, 八月的大會(huì)這家公司的老板又宣布了好消息。 用了這個(gè)疫苗根本不會(huì)復(fù)發(fā)， 在豬身上顯示成功 “[A] Vaxfectin®-formulated trivalent therapeutic version of the vaccine … significantly reduced (p<0.05) the recurrence of lesions in guinea pigs with latent infection as well as viral shedding.” In addition “… a 0.1 µg dose of the prophylactic vaccine provided 100% protection of mice against challenge with 50 times a lethal dose, and a 100 µg dose of the prophylactic vaccine provided 100% protection of mice against challenge with 500 times a lethal dose. The 100 µg dose of the prophylactic vaccine also significantly reduced viral shedding at the primary infection site (p<0.001) and inhibited viral counts at the latent infection site (pd0.05). Both the monovalent and trivalent vaccines completely eliminated primary disease and recurrent disease in a prophylactic guinea pig model.” To say these results are significant is understatement. However, whether or not Vical can achieve equally compelling results in the clinic with human subjects obviously is the key question, and one for which both the medical and financial communities await an answer. After all, according to Vical, estimated direct costs of treating HSV-2 in the United States alone are close to $1 billion annually, primarily for drugs and outpatient medical care, plus additional indirect costs of more than $200 million. If the company is successful in developing an FDA-approved HSV-2 vaccine formulated with its Vaxfectin® adjuvant, the revenues in the US alone would push VICL into biotech’s major leagues. 豬身上成功了不能說(shuō)明問(wèn)題， 人身上成功才是關(guān)鍵。 每一年在美guo在二型皰疹上的病人買藥消費(fèi)達(dá)到十億美金。 還有近兩億美金的間接消費(fèi)。 如果這家公司成功把此藥推向市場(chǎng) 那光是美guo的營(yíng)業(yè)額就是一個(gè)天文數(shù)字了吧。 （如果哪家公司在這各方面成功那將是創(chuàng)造神話， 不光是印鈔機(jī)了） ” 我的問(wèn)題是，人體試驗(yàn)成功可能性是不是仍然很小列？ 對(duì)于藥物研發(fā)，是不是大多數(shù)是在人體試驗(yàn)階段失敗的��？ 謝謝！ |
10樓2011-08-31 15:23:42
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