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lgq101木蟲 (小有名氣)
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[求助]
求一段有機合成翻譯~~~謝謝
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| A major goal in the field of diversity-oriented synthesis is the efficient production of small-molecule libraries that address underexploited regions of biologically relevant chemical space to enable the discovery of new biological probes and potential therapeutic lead compounds (1). A key approach to addressing this challenge is to emulate natural products and other biogenetic molecules, which have coevolved with macromolecular biological targets (2). Toward this end, a variety of natural product-based libraries have been synthesized, with promising early results (3). These libraries can be validated initially by evaluation of their structural and physicochemical properties using principal component analysis (PCA) to determine the regions of chemical space that are accessed. Subsequently, screening across a wide range of biological assays provides direct biological validation of the functional capabilities of these libraries. |

至尊木蟲 (小有名氣)
| 結(jié)構(gòu)多樣性合成領(lǐng)域的一個主要目標(biāo)是有效生產(chǎn)出小分子文庫,這些文庫能填補未開發(fā)的生物相關(guān)化合物的空間,從而能夠發(fā)現(xiàn)新的生物探針和能治病的先導(dǎo)化合物(1)。處理這項挑戰(zhàn)的關(guān)鍵方法是模擬天然化合物和其他生物分子,它們與大分子生物靶點共同進(jìn)化(2)。為了達(dá)到這一目標(biāo),有前景的多種天然產(chǎn)物文庫被合成(3)。這些文庫通過使用主要化合物分析(PCA)測定它們通過的化學(xué)空間域來評估它們結(jié)構(gòu)和理化性質(zhì),從而初步驗證了這些文庫的有效性。后來,在大范圍生物學(xué)分析的篩選直接證明這些文庫具有生物活性的功能。 |
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