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jiao1123

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Poly(ethylene oxide) (PEO) and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) are biocompatible polymers that have delivered clinically proven benefits in various biomedical applications. Biocompatible polymer vesicles were prepared on basis of the inclusion complexation between a-cyclodextrins (a-CDs) and double hydrophilic poly(ethylene oxide)-b-poly(2- methacryloyloxyethyl phosphorylcholine) (PEO-b-PMPC) in aqueous media without using organic
olvent. The supramolecular structure of the nano-sized vesicles was demonstrated by transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS). The biocompatibility of PEO-b-PMPC block copolymers and PEO-b-PMPC/a-CDs vesicles were studied by cell viability test, and the results revealed that both of them showed excellent cytocompatibility.
Hydrophilic doxorubicin (DOX$HCl) was successfully loaded into the vesicle with loading content of 10.3% and loading efficiency of 30%. The DOX$HCl loaded vesicles showed lower cytotoxicity than free drugs, and could efficiently deliver and release the drug into HepG2 cells as confirmed by fluorescence microscope (FM). With these properties, the polymer vesicles are attractive as drug carriers for pharmaceutical applications.

[ Last edited by jiao1123 on 2011-10-1 at 23:14 ]

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1樓 2011-10-01 21:21:24

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erics080

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愛與雨下(金幣+1): ！~ 2011-10-02 08:24:31
jiao1123(金幣+35, 翻譯EPI+1): 2011-10-04 21:22:06

PEO(聚氧乙烯)和PMPC(聚(2-甲基丙烯酰羥乙基磷酰膽堿))都是具有良好生物相容性的聚合物,在臨床方面被證實是可以用于多種生物醫(yī)藥方面的應(yīng)用.基于a-環(huán)糊精和兩親性聚合物poly(ethylene oxide)-b-poly(2- methacryloyloxyethyl phosphorylcholine) (PEO-b-PMPC),生物相容性的聚合物囊泡可以在水中組裝形成而不需要有機溶劑.這種納米級的超分子結(jié)構(gòu)由透射顯微鏡,原子力顯微鏡和動態(tài)光散射來表征.這種生物相容性的兩嵌段聚合物和聚合物/a-環(huán)糊精的細(xì)胞毒性研究證明兩者都具有優(yōu)秀的細(xì)胞相容性. 親水性的阿霉素(DOX.HCL)成功地裝載進聚合物囊泡中,其裝載量為10.3%,裝載效率是30%. 負(fù)載有DOX.HCL囊泡的毒性要小于純藥.負(fù)載的DOX.HCL可以有效地輸送并釋放進HepG2細(xì)胞中,實驗結(jié)果已被熒光顯微鏡證明. 由于這些優(yōu)點,聚合物囊泡作為藥物輸送應(yīng)用是非常有吸引力的.

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2樓2011-10-02 01:57:03

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