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[求助]
求助生物醫(yī)藥方面的翻譯就幾句話
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Poly (ADP-ribose) polymerase(PARP-1 and PARP-2) are the key enzymes responded to the DNA damage by the process of base excision DNA repair (BER) pathway to maintain the life circle of cell survive and proliferation. It has been reported that PARP inhibitors could potentiate the antitumor effects of chemotherapies and radiation therapy. Most importantly, PARP inhibitors could selectively kill cancer cells with BRCA (BRCA-1 and BRCA-2) defects which are lack of homologous recombination (HR) pathway of double-stranded DNA repair. These research results make PARP to be a potentially important therapeutic target for cancer patients. |
鐵桿木蟲(chóng) (正式寫(xiě)手)
有為青年
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多腺苷二磷酸多聚酶(PARP-1 及PARP-2) 是DNA堿基切除修復(fù)過(guò)程中負(fù)責(zé)DNA損傷修復(fù),是維系細(xì)胞生存、增殖的關(guān)鍵酶。 有報(bào)道稱,PARP抑制劑能夠加強(qiáng)化療、放療的抑癌效果。更重要的是,PARP抑制劑能夠選擇性殺死BRCA缺陷(BRCA-1 和BRCA-2)的癌細(xì)胞,BRCA缺陷的細(xì)胞丟失雙鏈DNA重組路徑。這些表明,PARP有可能成為癌癥治療新靶點(diǎn)。 |

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